Tag Archives: Sahlgrenska Academy

Infants sleeps in their own beds to reduce the risk of sudden death

STOCKHOLM, Feb. 8(Greenpost)–A new doctoral thesis shows that potential to save more lives exists if infants sleeps alone in their backs and the pregnant mother does not smoke.

In the early 1990s, the Swedish National Board of Health and Welfare went out with advice to new parents to reduce the number of children who die each year from SIDS. The advice stated that children sleep safest on their backs, that smoking during pregnancy is a risk factor, that children should not be kept too warm, that they should be able to move freely and that breastfeeding provided a certain amount of protection.

The preventative advice led to a sharp drop in the number of deaths from SIDS; from over a hundred children annually, to about twenty deaths per year in more recent years.

Risk and preventative factors have changed when the cases are fewer and have not been studied recently. In a new thesis at Sahlgrenska Academy, the University of Gothenburg, Per Möllborg, Child Health Medical Officer, has studied the different factors surrounding SIDS to enable further preventative work.

“The results show that more lives could potentially be saved if fewer babies slept on their stomachs or were placed on their sides, if fewer mothers smoked during pregnancy and if infants slept in their own beds in their parents’ bedroom during the first three months,” says Per Möllborg.

Children sleeping with their parents can be a risky situation during the first months. One of the thesis’ four studies examined co-sleeping. One out of five children slept with their parents at 6 months of age and it was even more common if the child was breastfed, had difficulty sleeping and woke often as well as if the mother was a single parent. If the child used a pacifier, co-sleeping was less common.

The thesis shows that current advice is relatively well followed, and that only one in 20 infants are laid down to sleep on their stomachs. Babies were more commonly sleeping on their stomachs if the mother was unemployed, smoked during pregnancy, if the child was irritable, shared a room with siblings or did not use a pacifier.

“This knowledge gives the Child Health Centers the opportunity to more precisely focus information and further reduce the number of babies placed on their stomachs,” says Per Möllborg.

One of the studies in the thesis showed that the risk of SIDS was greater if the parents did not live together, if the mother was young, had given birth to many children or if the baby was premature.

As sudden infant death syndrome has become less common, smoking has become a greater risk factor. Now, it is no longer more common for deaths during the winter months and the average age of sudden infant death has lowered from just under 3 months to 2 months, since introduction of the new advice in the early 1990s.

The research was done at Sahlgrenska Academy of Gothenburg University.

Diabetes medication could be used to treat alcohol dependence

By Xuefei Chen Axelsson

Stockholm, Sept. 12(Greenpost)–A new study on mice and rats at Sahlgrenska Academy shows that a medication used for diabetes and obesity also could be a valuable tool for the treatment of alcohol dependence.

gothenburg-sweden Alcohol dependence causes morbidity as well as mortality and is –major health problem in today’s society. The costs for alcohol dependence in Sweden are estimated to be around SEK 45 billion per year. Nearly 5 percent of the adult population in Sweden have been diagnosed with alcohol dependence, which corresponds to approximately 300 000 people. Even more Swedes have harmful alcohol consumption. Indeed, approximately 15 percent consume more than 14 standard drinks per week (men) or more than nine standard drinks per week (women).

images (1)A new study at Sahlgrenska Academy, University of Gothenburg, shows that interfering with the hormone GLP-1 could be a target for treating alcohol dependence, which is an entirely novel aspect.

Researchers have found that a medication that resemble GLP-1, which is used to treat type 2 diabetes as well as obesity, also could be used to treat alcohol dependence.

Usually, dopamine is released in the brain’s reward center in response to drinking alcohol, which leads to a sense of euphoria. The GLP-1-like substance prevents the ability of alcohol to increase dopamine in reward areas in the mice, suggesting that they no longer experience a reward from alcohol. In addition the diabetes medication caused the rats to decreases their alcohol intake, as well as reduced the motivation to drink alcohol in rats that were bred to drink a lot of alcohol. The medication also prevents relapse drinking in rats, which is major problem for alcohol dependent individuals.

“The GLP-1-like substance reduced the alcohol consumption by 30-40 percent in rats that drank large quantities of alcohol for several months” says Elisabet Jerlhag, researcher at Sahlgrenska Academy.

imagesSimilar mechanisms appear to regulate alcohol dependence and binge eating. The hormone GLP-1 is released from the intestines when we eat and causes satiety. It is also released in the brain and thereby reduces food intake.

“The results of the present study suggest that the physiological role of GLP-1 extends beyond glucose homeostasis and food intake regulation and includes modulation of development of alcohol dependence. In addition we suggest that medications that resemble GLP-1 could be used to treat alcohol dependence in humans. This will now be studied further,” says Elisabet Jerlhag at Sahlgrenska Academy.

The article The glucagon-like peptide 1 receptor agonist liraglutide attenuates the reinforcing properties of alcohol in rodents was published in the journal Addict Biology on August 25.

Link to article: http://www.ncbi.nlm.nih.gov/pubmed/26303264