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Lianhuaqingwen has not only mint but 13 ingredients

By Xuefei Chen Axelsson

STOCKHOLM, May 10, (Greenpost) — Swedish Radio and Aftonbladet reported on May 6 that Swedish Customs had tested the Chinese traditional herb content medicine Lianhuaqingwen which they confiscated and gave a conclusion that the medicine doesn’t function and only contains mint in it.

This report was spread to China and Chinese medical academicians and relevant organisations immediately reacted on this news saying that the Swedish conclusion was not right.

The news said Swedish official in Drugs Administration lab said he didn’t find enough evidence to show the medicine is useful because he only found mint in it, but didn’t mention anything else and claimed that there was no any relevant articles about it.

This conclusion shows that he didn’t find the article about Lianhuaqingwen, nor read it. He neither found nothing else in the medicine or he found something but he didn’t know what they were.

News from Chinese Dr. Li said in fact there were 13 ingredients or components in the medicine. But only mint has a well recognised chemical format while the other Chinese herbs didn’t have chemical format.

The 13 ingredients are Lianqiao which is Forsythoside E, Jinyinhua which is honeysukle, similar to dandelion, luding, Rutin, mahuang, dahuang, which is Epherdra, bitter apricot core, plaster, banlangen which is a well-known antivirus medicine in China. Banlangen was invented in mid 1990s. I remember once I was asked to translate the specifications of the medicine because my radio people were often asked to do this kind of translation job. But I refused to do it because I felt I knew so little about medicine knowledge. But over the years Banlangen has become a daily medicine like Alvedon in Sweden. If people have virus type of flu, people can take Banlangen. If they have bacteria type of cold, they can just take the ganmaochonji a kind of small particle type of powder and just putting it into a cup of hot water and drink it.

Mianmaguanzhong, I do not know what it is, but Yuxingcao is also a well known name in dealing with eyes, Huoxiang is also a very common but well effective Chinese medicine. Hongjingtian is produced in Tibet and famous for its function to help you to have enough oxegon. When we were in Tibet, a colleague felt he was lack of oxegon, he went to buy oxegon bottle and Hongjingtian. Gancao was also a Chinese medicine both in tablet form or in raw herb form. One can swallow tablet, but drink water which soaks the gancao herb. The last one is exactly mint.

Mint is indeed a good component for various kinds of Chinese medicine. Mint sugar in Lidl actually helps you if you have a sore throat.

Academician Zhong Nanshan who was the key person in leading the campaign against Covid-19. President Xi Jinping was leading the campaign by sending hospitals, doctors and nurses and all the supplies through various provinces, Zhong Nanshan was a symbol of technical part, a lot of information was sent out through Zhongs name. Academician Zhang Boli who has retired at home, but he was summoned to lead in the campaign with his rich Chinese medicine knowledge. They both are authoritative while Zhong was in western medicine and Zhang was in Chinese medicine. But both recommended Lianhuaqingwen. During China’s campaign against covid-19, it was a perfect example of cooperation and combination of Chinese and western medicines.

Let’s look at the corona virus again. It is a virus, but the symptom when people catch it is coughing, fever, running or drying nose and fatigue. Thus the symptom is similar to a serious cold. Only when people are either too weak or too healthy to fight against the virus with no strength or too much strength, fiercely, then it hurt your organs especially the lung. The most typical symptom in the end is respiratory problem. But at the beginning, you just got a cold.

And all these components or ingredients of Lianhuaqingwen are useful in fighting against cold. Thus it can almost be treated as a most powerful kind of medicine in treating cold.

According to a joint study by researchers in Nanjing Chinese Medicine University and Shanghai Drug Research Institute under the Chinese Academy of Sciences, Lianhuaqingwen is so far the most functional medicine in inhibiting corona virus from reproduction and curing the fever of the patients.

According to Professor Fang Bangjiang from Longhua Hospital of Shanghai Chinese Medicine University, there were only 20-30 percent of the patients have fever. Most of them did not have fever. He was sent to Leishenshan Hospital China built within ten days after the closedown of Wuhan on January 23. ( link http://www.greenpost.se/2020/05/02/%e9%9b%b7%e7%a5%9e%e5%b1%b1%e6%8a%97%e7%96%ab%e4%b8%93%e5%ae%b6%e6%96%b9%e9%82%a6%e6%b1%9f%e6%95%99%e6%8e%88%e7%9b%b4%e6%92%ad%e4%b8%8e%e7%91%9e%e5%85%b8%e3%80%81%e7%be%8e%e3%80%81%e5%8a%a0%e3%80%81/)

Fang was in charge of a unit which had 108 patients who had light symptoms. He found that the patients had one unified symptom, that was panic and fear, worries and weak nerves. After trying western medicine for one week, he found it not only did not give positive results but give negative effects on liver. Thus he prescribed all the time Chinese medicine after a week. The Chinese medicine mainly calmed down the patients, relieved them from panic feelings and got them sleep better.

As a result, no one became more serious and no death happened in his unit. In comparison, those who were treated with western way or medicine, a lot of them could become worse and were sent to ICU.

According to the research paper, Lianhuaqingwen was used for severe patients too and by alleviating their fever or other symptoms, lives were rescued.

But so far, experts admit that there were no cure all kind of medicine against covid-19. But as a supportive medicine or healthy product, those who are confirmed to get covid-19 positive, they can take Lianhuaqingwen. Whether it works or not, one can feel it after three days. If after three days it did not function, you feel worse, then you must call the doctor again.

Sweden has tried its best to deal with the covid-19 and avoided the problem China had at the beginning of getting the hospital too crowded and almost collapse. Sweden wanted to let the covid-19 happen slowly, which is a good idea.

However, the virus loves people and can quickly spread from one person to two persons if you have close contacts, for example in crowds, not necessarily to kiss each other. It can spread through spit and sneeze or cough. But if people keep themselves isolated, the virus couldn’t find another person to reproduce itself, it will die with the recovery of the person. Thus isolation is very very important.

The earlier, quicker to isolate, the better. For example, if Swedish cancelled the travel, canceled the Eurovision, canceled the birthday party, and isolated quicker and earlier in other areas where you just found a couple of cases, then the virus probably got wiped out by now. But no one knows. Maybe it would take two to three months any way.

Thanks to Swedish people who are good at keeping social distance and mostly follow the government instructions, Swedish people did not sacrifice too much freedom and the society continues to function, which can be seen as a positive aspect. But if people especially those who got infected, but not to the extend to go to hospitals intensive care, maybe if they take the Lianhuaqingwen, it can not only comfort them, but also prevent them from getting worse.

To say it just got mint in it and does not function, it sounds like it is just the mint candy. But it is simply not true.

In fact, Lianhuaqingwen was just one of the Chinese medicines that dealt with covid-19. I guess it became famous because of its mass production and packaging. Qingfei Paidu Tang or Lung cleaning and poison eradicating syrup was also very popular during covid 19 campaign in Wuhan, Central China. But this kind of medicine is pure herb and needs to be boiled each time for each person. It is hard to get mass production. Chinese doctors also stressed that it was one person with his or her own prescription according to his or her own symptom.

Chinese medicine does not stress killing the virus or fighting the virus, instead, it stressed that the medicine helps patients to get stronger in immune system and physical strength by getting rid of or alleviating the symptom.

Covid-19 is indeed a strong virus which is very hard to deal with because it reproduces itself so quickly once it entered humans body and attacked the lung. By fighting back with the immune system, patients other organs such as liver or heart or kidney could be damaged too. That was why a lot of people died of not only virus, but also several other combined diseases. The virus can damage your immune system. Thus, the Chinese doctors emphasized that people should eat enough protein and sleep well. Getting yourself strong is the key to deal with the covid 19.

The following is the research paper about Lianhuaqingwen.

Pharmacological Research:Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

Elsevier

Pharmacological Research

Available online 20 March 2020, 104761In Press, Journal Pre-proofWhat are Journal Pre-proof articles?

Pharmacological Research

Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)

Author links open overlay panelLiRunfenga1HouYunlonge1HuangJichengd1PanWeiqia1MaQinhaiaShiYongxiadLiChufangaZhaoJinaJiaZhenhuaeJiangHaimingaZhengKuidHuangShuxiangdDaiJundLiXiaobodHouXiaotaocWangLincZhongNanshanaYangZifengabcShow morehttps://doi.org/10.1016/j.phrs.2020.104761Get rights and content

Abstract

Purpose

Lianhuaqingwen (LH) as traditional Chinese medicine (TCM) formula has been used to treat influenza and exerted broad-spectrum antiviral effects on a series of influenza viruses and immune regulatory effects [1]. The goal of this study is to demonstrate the antiviral activity of LH against the novel SARS-CoV-2 virus and its potential effect in regulating host immune response.

Methods

The antiviral activity of LH against SARS-CoV-2 was assessed in Vero E6 cells using CPE and plaque reduction assay. The effect of LH on virion morphology was visualized under transmission electron microscope. Pro-inflammatory cytokine expression levels upon SARS-CoV-2 infection in Huh-7 cells were measured by real-time quantitative PCR assays.

Results

LH significantly inhibited SARS-CoV-2 replication in Vero E6 cells and markedly reduced pro-inflammatory cytokines (TNF-α, IL-6, CCL-2/MCP-1 and CXCL-10/IP-10) production at the mRNA levels. Furthermore, LH treatment resulted in abnormal particle morphology of virion in cells.

Conclusions

LH significantly inhibits the SARS-COV-2 replication, affects virus morphology and exerts anti-inflammatory activity in vitro. These findings indicate that LH protects against the virus attack, making its use a novel strategy for controlling the COVID-19 disease.

Keywords

LianhuaqingwencoronavirusSARS-CoV-2anti-inflammatory

1. Introduction

Coronaviruses are a group of enveloped viruses named for their coronary appearance with positive single-stranded RNA genomes [2]. In addition to six known strains of coronaviruses that are infectious to humans, a novel coronavirus (SARS-CoV-2) was detected recently in Wuhan, China [3,4]. Like the other two highly pathogenic coronaviruses SARS-CoV and MERS-CoV, SARS-CoV-2 also caused severe respiratory illness and even death. Moreover, the population’s susceptibility to these highly pathogenic coronaviruses has contributed to large outbreaks and evolved into the public health events, highlighting the necessity to prepare for future reemergence or the novel emerging viruses [5].

Similar to SARS-CoV and MERS-CoV, SARS-CoV-2 is initiated by zoonotic transmission likely from bats and spreads rapidly among humans [6]. The basic reproduction number (R0) of person-to-person spread is about at 2.6, which means that the SARS-CoV-2 infected cases grow at an exponential rate. As of February 07, 2020, 57,620 cases of the SARS-CoV-2 have been reported in China, including 26,359 suspected cases, and a sustained increase is predictable. The initial patient cluster with confirmed SARS-CoV-2 infection was reported Wuhan pneumonia with unknown aetiology, which bore some resemblance to SARS-CoV and MERS-CoV infections and was associated with ICU admission and high mortality. Moreover, High concentrations of cytokines were recorded in plasma of patients requiring ICU admission, such as GCSF, IP10, MCP1, MIP1A, and TNFα, suggesting that the cytokine storm was associated with disease severity [7]. A retrospective clinical study indicated the risk of fatality among hospitalized cases at 4.3% in single-center case series of 138 hospitalized patients [8], and the infection fatality risk could be below 1% or even below 0.1% in a large number of undetected relatively mild infections [9]. However, It is challenging to judge the severity and predict the consequences with the information available so far. Since no specific antiviral treatment for COVID-19 is currently available, supportive cares, including symptomatic controls and prevention of complications remain the most critical therapeutic regimens, especially in preventing acute respiratory distress syndrome [10]. Although the control of SARS-CoV-2 still presents multiple challenges in the short term, more potent antiviral drugs are urgent to be developed [4].

At present, some drugs are effective in eliminating SARS-CoV-2 and improving symptoms. The most promising antiviral drug for SARS-CoV-2 is remdesivir that is currently under clinical development for the treatment of Ebola virus infection [11]. However, the efficacy and safety of remdesivir for SARS-CoV-2 pneumonia patients need to be assessed by further clinical trials. In addition, in the prevention and treatment of COVID-19, Tranditonal Chinese medicines have received broad adoption, especially in treating cases of mild symptoms [12]. Lianhuaqingwen (LH), a Chinese patent medicine composed of 13 herbs, has played a positive role in the treatment of SARS-CoV-2. A retrospective analysis of clinical records was conducted in the SARS-CoV-2 infected patients at Wuhan Ninth Hospital and CR & WISCO General Hospital. LH combination could significantly relieve cardinal symptoms and reduce the course of the COVID-19 [13], making it successively included in the Guideline for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Pneumonia (On Trials, the Fourth/Fifth/Sixth/Seventh Edition) issued by National Health Commission of the People’s Republic of China and also recommended by 20 provincial health commissions including Hubei, Beijing, and Shanghai as well as National Administration of Traditional Chinese Medicine for the treatment of COVID-19. Moreover, LH exerted broad-spectrum effects on a series of influenza viruses by inhibiting viral propagation and regulating immune function and achieved similar therapeutic effectiveness with Oseltamivir in reducing the course of H1N1 virus infection [1,14,15]. Notably, the anti-influenza activity of LH in infected mice might depend on the regulation of cytokines, particularly in cytokine storm associated cytokines, such as IP-10, MCP-1, MIP1A, and TNF-α [1]. In the present study, we evaluated the antiviral and anti-inflammatory efficiency of LH against a clinical isolate of SARS-CoV-2 from Guangzhou in vitro.

2. Materials and Methods

2.1. Cell lines and virus

The African green monkey kidney epithelial (Vero E6) cells and the human hepatocellular carcinoma (Huh-7) cells were cultured in Dulbecco’s Modified Eagle’s medium (DMEM, Gibco, USA) supplemented with 10% fetal bovine serum (FBS) at 37 °C. A clinical isolated SARS-CoV-2 virus (Genebank accession no. MT123290.1) was propagated in Vero E6 cells, and viral titer was determined by 50% tissue culture infective dose (TCID50) according to the cytopathic effect by use of Reed-Muench method [17]. All the infection experiments were performed in a biosafety level-3 (BLS-3) laboratory.

2.2. Reagent preparation

LH capsule (Lot No.A2001108) was obtained from Yiling Pharmaceutical Co. Ltd. (Shijiazhuang, China). UPLC fingerprints of LH consist of 32 common peaks. 9 of 32 common peaks are identified. The similarities in 10 batches of LH Capsules samples were all above 0.96 (Supplementary Fig. 1). The black powder of raw material of LH was first dissolved in dimethyl sulfoxide (DMSO) to 240 mg/mL. After shaking for 30 min at room temperature, the LH solution was diluted with serum-free DMEM to 24 mg/mL as a stock solution and stored at −20 °C before using. Remdesivir was kindly provided by Prof. Jiancun Zhang from Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences and was dissolved in DMSO to 100 mM and stored at −20 °C before using. DMEM with 2% FBS was used as the dilution buffer in the follow-up experiments.

2.3. Cytotoxicity assay

The cytotoxic effects of the LH on Vero E6 and Huh-7 cells were evaluated by Methyl Thiazolyl Tetrazolium (MTT) assay. Briefly, monolayers of Vero E6 cells and Huh-7 cells in 96-well plates were rinsed with phosphate-buffered saline (PBS) followed by incubation with indicated concentrations of LH. After 72 h, the cells were stained with MTT solution at 0.5 mg/mL for 4 h. The supernatants were then removed, and the formed formazan crystals were dissolved in 200 μL DMSO. The absorbance was measured at 490 nm using Multiskan Spectrum reader (Thermo Fisher, USA). The 50% cytotoxic concentration (CC50) was calculated by the GraphPad Prism 7.0 software.

2.4. Cytopathic effect (CPE) inhibition assay

The Vero E6 cell monolayers were grown in 96-well plates and inoculated with 100 TCID50 of coronavirus strains at 37 ̊C for 2 h. The inoculum was removed, and the cells were subsequently incubated with indicated concentrations of LH or the positive control remdesivir. Following the 72 h of incubation, the infected cells shown 100% CPE under the microscope. The percentage of CPE in LH-treated cells were recorded. The 50% inhibition concentration (IC50) of the virus-induced CPE by LH was calculated by the Reed-Muench method [17].

2.5. Plaque reduction assay

The Vero E6 cell monolayers in 6-well plates were infected with 50 plaque-forming units (PFU) of SARS-CoV-2 for 2 h at 37 °C. After incubation, the cell monolayers were covered with agar overlay (final concentration: 0.6% agar, 2% FBS, indicated concentrations of LH or remdesivir). The plates were then incubated for 48 h at 37 °C with 5% CO2. Subsequently, the agar overlays were removed, and the cell monolayer was fixed with 10% formalin, stained with 1% crystal violet, and then the plaques were counted and photographed.

2.6. RNA isolation and reverse transcriptase-quantitative PCR analysis (RT-qPCR)

The Huh-7 cell monolayers in 12-well plate were rinsed with PBS and then exposed to coronavirus at a multiplicity of infection (MOI) of 1 for 2 h at 37 °C. The inoculum was removed and replaced with the indicated concentrations of LH or mock-treated with DMEM supplemented with 2% FBS for subsequent 48 h incubation at 37 °C with 5% CO2. The cells were then harvested for RNA isolation and qPCR as described previously [16]. The primer and probe sequences used for analysis are listed in Supplementary Table 1. The relative mRNA expression was calculated using the 2-△△Ct method with GAPDH as an internal reference gene.

2.7. Electron microscope

Monolayers of Vero E6 cells in 6-well plates were incubated with SARS-CoV-2 at a MOI of 0.001 for 2 h at 37 °C. The virus inoculum was then removed and replaced with DMEM medium supplemented with 2% FBS containing LH (600 μg/mL) or remdesivir (5 μM). At 48 h p.i., the cells were fixed, dehydrated and embedded as described previously [18]. Ultrathin sections (70 nm) of embedded cells were prepared, deposited onto Formvar-coated copper grids (200 mesh), stained with uranyl acetate and lead citrate, and then observed under JEM-1400 PLUS transmission electron microscopy (Japan Electron Optics Laboratory Co., Ltd., JEM-1400 PLUS).

2.8. Statistical Analyses

Statistical analysis was performed using GraphPad Prism 7.0 software. The differences in mRNA expression levels of cytokines were compared using a one-way analysis of variance (ANOVA). Values of p < 0.05 was considered to be statistically significant.

3. Results

3.1. Antiviral activity of LH on SARS-CoV-2 in vitro

The cell viability after LH or remdesivir treatment was determined by MTT assay in both Vero E6 and Huh-7 cells. LH showed unapparent cytotoxicity for both cell lines at concentrations up to 600 μg/mL (Fig. 1A, C). The positive control remdesivir showed no cytotoxicity to cells at a concentration of 50µM (Fig. 1B, D).

Fig. 1

To investigate the antiviral effect of LH against SARS-CoV-2 virus, the Vero E6 cells were infected with 100 TCID50 of virus and incubated with LH at various concentrations for 72 h. As shown in Fig. 2A, LH inhibited the replication of SARS-CoV-2 virus with an IC50 value of 411.2 µg/mL by CPE assay (Fig. 2A). Meanwhile, treatment with LH following infection also had a dose-dependent inhibitory effect on plaque formation of the SARS-CoV-2 virus (Fig. 2C). We selected remdesivir as the positive control in our study and the results showed that remdesivir potently inhibited virus-induced CPE with an IC50 of 0.651 µM and a total plaque formation inhibition at 5 μM (Fig. 2B, C).

Fig. 2

To further confirm the efficacy of LH in inhibiting SARS-CoV-2 virus replication in cells, we detected the viral particles in ultrathin sections of infected cells under electron microscopy. At 48 h p.i., viral particles were found in cytoplasm, intracellular vesicles, endoplasmic reticulum, and cell membrane and presented spherical crown-like appearance, which was typical coronavirus morphology (Fig. 3B, G). LH (600 μg/mL) and positive control remdesivir (5 μM) treatment resulted in a reduction of the number of virions compared with mock-treated infected cells (Fig. 3G–J). It was interesting to note that some virions in the surface of LH-treated cells presented spindle sharp which was in contrast to the typical spherical particles in the mock-treated cells (Fig. 3I).

Fig. 3

3.2. Inhibition of SARS-CoV-2-induced cytokine and chemokine expression by LH in vitro

To determine the effect of LH on the expression of cytokines and chemokines induced by SAR2-CoV-2, the mRNA expression levels of TNF-α, IL-6, CCL-2/MCP-1, and CXCL-10/IP-10 were detected and compared between the LH-treated and mock-treated Huh-7 cells. The results showed that the elevated expressions of these four cytokines were significantly inhibited by LH treatment in a concentration-dependent manner (Fig. 4).

Fig. 4

4. Discussion

Starting from December 2019, a pandemic of respiratory illness caused by a novel coronavirus named SARS-CoV-2 is sweeping the mainland of China. This virus has spread to several foreign countries, threatening to trigger a global outbreak. Several antiviral agents can be envisaged to control or prevent viral infections by antiviral assay in vitro [14,17]. However, the efficacy and safety of novel candidates need validations in vivo, even for those clinically approved medicines, which means that it will take months to years for clinical practices. At present, symptomatic and supportive treatments remain key to clinical practices. Thus, Traditional Chinese Medicines (TCM) carried both the antiviral effect and the symptomatic relief might bring more clinical benefits [12]. As a classical TCM prescription for respiratory diseases, LH is the only approved medicine in the treatment of SARS and influenza. After the outbreak of SARS-CoV-2, LH as a representative TCM prescription was recommended again in the latest Guideline for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Pneumonia issued by National Health Commission of the People’s Republic of China The purpose of this study was to demonstrate whether the therapeutic effects of LH on the COVID-19 targeting virus replication and immunological regulation as it did on the infection caused by influenza viruses.

Our previous study showed that LH exhibited in vitro anti-influenza activity with IC50 ranging from 200-2000 μg/mL [1]. Here we demonstrated that LH also has a comparable antiviral potency against the SARS-CoV-2 virus with an IC50 value of 411.2 μg/mL (Fig. 2). Transmission electron microscopy (TEM) has been a potent tool to observe virus entry, virus particle assembly, viral ultrastructure, and budding from the plasma membrane [17]. To understand the antiviral details of LH, EM pictures were taken from each group. Abundant virus particles assembled at the surface of membrane, cytoplasm, and plasma vesicles in the SARS-CoV-2 infected cells, decreased in the treatment of LH at 600ug/mL. Notably, slight deformation of virus particles was seen in the LH treatment, which required us to make further studies.

Highly pathogenic coronaviruses such as SARS-CoV and MERS-CoV cause fatal pneumonia, which is mainly associated with rapid virus replication, massive inflammatory cell infiltration and elevated proinflammatory cytokine/chemokine responses. Although the pathophysiology of fatal pneumonia caused by highly pathogenic coronaviruses has not been completely understood, accumulating evidence suggests that the cytokine storm plays a crucial role in causing fatal pneumonia [18]. Excessive amounts of proinflammatory cytokines were reported (e.g., IL-1β, IL-6, IL-12, IFN-γ, IP-10, and MCP-1) in the serum of SARS patients [18], similar in the serum of MERS patients [19]. Chaolin Huang et al. confirmed the occurrence of the cytokine storm in the COVID-19 patients in ICU rather than those in non-ICU patients [7]. Based on the excessive cytokines responses, Suxin Wan et al. claimed that IL-6 and IL-10 levels could be used as one of the bases for predicting the outcome and prognosis of the COVID-2019 [20]. In this study, host cells infected with HCoV-229E and SARS-COV-2 increased the cytokine release such as TNF-α, IL-6, CCL-2/MCP-1, and CXCL-10/IP-10, which was suppressed by LH in a dose-dependent manner. The change of cytokine profiles suggested that LH might have a potential effect on the inhibition of cytokine storm induced by SARS-COV-2, which also needed to be validated in vivo.

5. Conclusion

Since the launch of LH, it has been widely used as a broad spectrum of antiviral agent in the clinical practice, especially for various respiratory virus infections. Previous studies have shown that LH a broad spectrum of effects on a series of influenza viruses by interfering with both viral and host reactions. Although LH significantly relieved the clinical symptoms of the COVID-19, the underlying mechanism of antiviral effects on coronavirus, especially in the SARS-COV-2, was still elusive. In this study, we demonstrated that LH exerted its anti-coronavirus activity by inhibiting virus replication and reducing the cytokine release from host cells, which supported the clinical application of LH in combination with existing therapies to treat COVID-2019.

Acknowledgements

The study was funded by Beijing Municipal Science and Technology Commission NCP Emergency Project; Hebei Provincial Department of Science and Technology NCP prevention and control emergency scientific research project (Grant no. 20277708D); The Science research project of the Guangdong Province (Grant no. 2020B111110001); Daxing District Science and technology development projects (Grant no. KT202008013).

Appendix A. Supplementary data

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References

[1]Y. Ding, et al.The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune functionBMC Complement Altern Med, 17 (1) (2017), p. 130CrossRefGoogle Scholar[2]T.S. Fung, D.X. LiuHuman Coronavirus: Host-Pathogen InteractionAnnu Rev Microbiol, 73 (2019), pp. 529-557CrossRefView Record in ScopusGoogle Scholar[3]A. Du ToitOutbreak of a novel coronavirusNat Rev Microbiol (2020)Google Scholar[4]W.G. Carlos, et al.Novel Wuhan (2019-nCoV) CoronavirusAm J Respir Crit Care Med (2020)Google Scholar[5]J. NkengasongChina’s response to a novel coronavirus stands in stark contrast to the 2002 SARS outbreak responseNat Med (2020)Google Scholar[6]P. Zhou, et al.A pneumonia outbreak associated with a new coronavirus of probable bat originNature (2020)Google Scholar[7]C. Huang, et al.Clinical features of patients infected with 2019 novel coronavirus in Wuhan, ChinaLancet (2020)Google Scholar[8]D. Wang, et al.Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, ChinaJAMA (2020)Google Scholar[9]P. Wu, et al.Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020Euro Surveill, 25 (3) (2020)Google Scholar[10]A. Zumla, et al.Coronaviruses – drug discovery and therapeutic optionsNat Rev Drug Discov, 15 (5) (2016), pp. 327-347CrossRefView Record in ScopusGoogle Scholar[11]S. Mulangu, et al.A Randomized, Controlled Trial of Ebola Virus Disease TherapeuticsN Engl J Med, 381 (24) (2019), pp. 2293-2303CrossRefView Record in ScopusGoogle Scholar[12]J.-l. Ren, A.-H. Zhang, X.-J. WangTraditional Chinese Medicine for COVID-19 TreatmentPharmacological Research (2020), p. 104743ArticleDownload PDFGoogle Scholar[13]K Yao, et al.Retrospective Clinical Analysis on Treatment of Novel Coronavirus-infected Pneumonia with Traditional Chinese Medicine Lianhua QingwenChinese Journal of Experimental Traditional Medical Formulae (2020), pp. 1-7CrossRefGoogle Scholar[14]H. LuDrug treatment options for the 2019-new coronavirus (2019-nCoV)Biosci Trends (2020)Google Scholar[15]Z.P. Duan, et al.Natural herbal medicine Lianhuaqingwen capsule anti-influenza A (H1N1) trial: a randomized, double blind, positive controlled clinical trialChin Med J (Engl), 124 (18) (2011), pp. 2925-2933View Record in ScopusGoogle Scholar[16]Z. Li, et al.Radix isatidis Polysaccharides Inhibit Influenza a Virus and Influenza A Virus-Induced Inflammation via Suppression of Host TLR3 Signaling In VitroMolecules, 22 (1) (2017)Google Scholar[17]M. Wang, et al.Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitroCell Res (2020)Google Scholar[18]H.N. Leong, et al.Clinical and laboratory findings of SARS in SingaporeAnn Acad Med Singapore, 35 (5) (2006), pp. 332-339View Record in ScopusGoogle Scholar[19]A. Assiri, et al.Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive studyLancet Infect Dis, 13 (9) (2013), pp. 752-761ArticleDownload PDFView Record in ScopusGoogle Scholar[20]S. Wan, et al.Characteristics of lymphocyte subsets and cytokines in peripheral blood of 123 hospitalized patients with 2019 novel coronavirus pneumonia (NCP)medRxiv (2020)p. 2020.02.10.20021832Google Scholar

Chinese demand of Port contribute to Finland’s food export

By Xuefei Chen Axelsson

STOCKHOLM, November 28(Greenpost)– While the trade negotiation between China and the US is underway at a critical time, news from Finland reaching here says that Finland’s exports in the food and beverage sector see a record high this year partly due to China’s demand of pork and other products.

The export forecast for 2019 is EUR 1.75 billion, which, if achieved, would represent a record high.

Entry into new markets, along with an increase in export volumes and prices, have contributed to an increase in the value of exports. Awareness of the growth potential available through exports has grown in the food and beverage sector. New export companies have participated in the Food from Finland programme created by Business Finland and funded by the Ministry of Agriculture and Forestry and the Ministry of Economic Affairs and Employment. The food authorities and other promoter organisations have also significantly contributed towards the export growth.

Products in particularly strong demand this year have included dairy products, oats, other foodstuffs and alcohol products. Countries where export growth has been visible include China, where there has been a particular demand for pork and powdered milk.

The value of food imports to Finland was triple the value of our exports at EUR 4.6 billion in 2018. Many of the products being imported are not produced or manufactured in Finland. In order to reduce the trade deficit, it would be important to increase the added value of exports.

The food industry is a significant industry in Finland

According to preliminary figures for 2018, the total turnover of the food industry was around EUR 11.2 billion, showing an increase of 4% on the previous year. The food industry employs some 38,000 people directly, and as many as 340,000 indirectly.

– Finnish consumers buy domestic, responsibly produced foods, which means the food industry will continue to be a very important sector in Finland. But in addition, Finnish products and raw materials are increasingly finding their way onto the plates and into the glasses of international consumers, too, says Leena Hyrylä, Food Industry Sector Manager at the Southeast Finland ELY Centre.

Food and beverage companies continue to seek growth

The sector barometer for the manufacture of food products indicates that SMEs in the food sector continue to be growth-driven. More than half of the SMEs that responded said they were pursuing growth; 22 per cent said they sought powerful growth, while 43 per cent said they would tap into any growth opportunities available. According to the barometer, SMEs in the food sector, especially in the beverage sector, were more growth-oriented than companies in comparable sectors.

SMEs in the food sector were more optimistic about the general outlook for the economy than other Finnish SMEs and those engaged in comparable sectors. However, expectations are down on the previous year.

The business environment is changing rapidly, placing a stronger focus on the consumer and on continued renewal. The food sector is influenced by current trends and themes such as climate change, demographic changes, scarce resources, digitalisation and technological advancement in general. Consumer awareness and expectations for products and food services are rising. Responsibility, wellbeing and domestic origin are rising trends.

Business Sector Services

  • A network of expertsled by the Ministry of Economic Affairs and Employment
  • compiles, analyses and communicates information avout the business enviroment for decision-making purposes
  • the objective is to facilitate the succes, growth and internationalisation of Finnish companies.

SME sector reports are based on an annual SME Barometer commissioned by the Ministry of Economic Affairs and Employment, the Federation of Finnish Enterprises and Finnvera Oyj. The SME Barometer conducted in the autumn of 2019 is based on responses from representatives of 6,133 small and medium-sized enterprises. The survey was conducted in summer 2019. Responses were provided by 196 SMEs in the food sector.

Chinese has a saying that the earth is round and if the sun is not shining in the east, it must be shining in the west. Or if not in the north, it must be in the south. Please do not just hang yourself in one tree.

Xinjiang Photo Exhibition held in Stockholm

By Xuefei Chen Axelsson

STOCKHOLM, Nov. 27(Greenpost, chineseonline) — While the dark and rainy weather made people sad and lonely, a warm Xinjiang Photo Exhibition has been held in Stockholm recently.

The exhibition was held by Green Post(www.greenpost.se) and Chinese Online(www.chineseonline.se) in cooperation with China Europe Cultural Association and ABF(Swedish Workers Association) at the citykonferensen in Stockholm.

Xuefei Chen Axelsson, Chief Editor and photographer of Green Post and freelance journalist said the exhibition came against the background that she was invited to attend a journalistic trip to Xinjiang in August 2018 together with journalists from 13 countries along the belt and road routes. And after that she went to Xinjiang twice respectively in March to Turpan after the National People’s Congress and National Day celebration in Beijing to personally experience the atmosphere in Urumqi city, capital of Xinjiang Ugyor Autonomous Region.

“I was impressed by the journeys and felt that Xinjiang now is very safe to travel and the cultural and tourist resources were rich. During my journey, I can feel business in Grand Bazar is booming and the ugyors dancing and singing were wonderful. Thus, I like to share this feelings and impressions with all the people who are interested in Xinjiang. “said Chen Axelsson.

The purpose is to share the information about the living picture in Xinjiang. The exhibition focuses on Xinjiangs infrastructure such as the fast train, subways and wide road, busy business in Grandbazar, music and art, dancing, beautiful scenery and environmental protection.

To let people have a taste of Xinjiang music and song, Luan Dehan played violin Why the flower is so red.

Artist Zhu Yingying sang the song which was about love between a woman and a ugyor soldier and moved all the audience. A whole generation of people were moved by the film and the song in China’s 80s.

Duan Maoli, President of Swedish Anhui Sci-Tech and Commerce Association expressed his appreciation for the exhibition.

“I would like to say thanks to Xuefei for holding such an exhibition. The media under her leadership is a professional media. With this exhibition, we can see the beautiful Xinjiang and the safe Xinjiang. I like to say it should be A beautiful Xinjiang forever!”

Zhu Jinchuan, General Manager of Air China in Stockholm also looked at the exhibition.

He said it was impressive to see these photos. Watching these beautiful pictures let people feel the life there is quite colourful and it is easy to visit there with Air China because the airlines can fly there directly from Beijing. It can also fly directly to other cities.

Journalists from PROFOCA and FPA attended the exhibition. Swedish innovation entrepreneur Skycab manager Åker Aredal also attended the exhibition. He was quite excited to see President Xi’s photo with Ugyor people and even recalled the moment when he was with President Xi and presented him a letter.

During the exhibition, Xuefei Chen Axelsson also made a presentation about the pictures and added more pictures about the daily lives there in the Grand Bazar. She illustrated the stories behind every photo.

During the exhibition, Axelsson also answered some questions.

Many visitors said they learnt a lot about Xinjiang and felt glad that the situation is safe and secure and life is lively there. Some even said they like to visit Xinjiang some day.

More lively photos in Grand Bazar and Turpan.

Photo and text by Xuefei Chen Axelsson

photo by Xuefei Chen Axelsson

Ma Jianzhong, Chairman of WFCMS leading a delegation Visits Sweden

By Xuefei Chen Axelsson

STOCKHOLM, Nov. 20(Greenpost)– Ma Jianzhong, Chairman of World Federation of Chinese Medicine Societies (WFCMS) led a large delegation of over 30 members to visit Sweden in order to make academic exchanges and field study on November 13th.

This was right after they attended the 16th World Congress of Chinese Medicine which was successfully held in Budapest, Capital of Hungary. The delegation includes leading experts and specialists in the field of Chinese medicine.

       At 10:30 in the morning, Chairman Ma Jianzhong, former Vice Minister of Health, Professor She Jing, who was also founding Chairman of the World Federation of Chinese Medicine Societies, and Professor Li Zhenji, Vice founding Chairman and Secretary-General of WFCMS and other six people came to the Chinese Embassy in Stockholm at the invitation of Chinese Ambassador Gui Cuiyou.

They were warmly welcomed and Ambassador Gui made extensive talks on the development of traditional Chinese medicine acupuncture and moxibustion in Sweden, and further explored how to further promote Chinese medicine culture and relieve the suffering of the Swedish people and overseas Chinese.

Counselor Dai Gang of Science and Technology at the Embassy and President Yang Chungui of the Swedish Society of Chinese Medicine gave a detailed introduction about the operation of Swedish traditional Chinese medicine and acupuncture clinics and the exchanges and cooperation with Western doctors such as those from Karolinska Hospital.

Jiemei, a lawyer at Guohao Law Firm, introduced the work of promoting acupuncture legislation in Sweden. After the talks, the Embassy arranged a lunch for all the guests.

After thorough inspection by the leaders of the World Federation of China and the friendly consultation between the two sides, they jointly decided that the World Federation of Chinese Medicine Professional Level Recognition Department and the Swedish Society of Chinese Medicine will sign a cooperation framework agreement on the “Cooperation on the clinical superiority technology transfer of traditional Chinese medicine and the evaluation of professional titles of international Chinese medicine”.

At 3 o’clock in the afternoon, under the witnesses of the WFCMS’ leaders and Guo Hao law Firm’s lawyer Jiemei, Professor Zheng Yuexian, the chief expert of the WFCMS and President of the Swedish Association of Chinese Medicine, Yang Chungui signed this important agreement.

 On the morning of the 14th, the World Federation of Chinese Medicine Societies experts visited Karolinska Institutet. The former Nobel Prize jury chair Professor Silas introduced the Karolinska Institute and Nobel Prize evaluation process to the delegation.

In the afternoon, the delegation concluded the intense academic study tour and flew back to China with Air China.

The World Federation of Chinese Medicine Societies is an international academic organization approved by the Chinese State Council and a member of the World Health Organization. It’s a Non-Governmental Organization (NGO). 

(Translated and edited by Xuefei Chen Axelsson )

第五届世界浙商大会签约金额超3000亿元 系历届之最

第五届世界浙商大会签约金额超3000亿元系历届之最

    大会现场。 张斌 摄

  北欧绿色邮报网援引中新社( 记者 张斌 )报道:13日,第五届世界浙商大会(下称:大会)在杭州开幕,吸引来自全球各地的近2800名浙商代表与会。大会签约项目协议总投资达3000亿元以上,系历届之最。

  据了解,大会拟签约项目主要围绕浙江“四大”建设(大湾区大花园大通道大都市区建设)、“八大万亿产业”、“长三角一体化”和数字经济、生命健康、高端装备、文化旅游和能源环保等重点产业。

  大会开幕式上,浙江为侨服务全球通平台、浙江省金融综合服务平台、浙江省企业服务综合平台正式开通,将为全球浙商提供更好服务。大会还表彰了“高质量发展”领军企业,颁发2019全球浙商金奖,激励浙商,争当高质量发展排头兵。

浙江为侨服务全球通平台、浙江省金融综合服务平台、浙江省企业服务综合平台正式开通。 张斌 摄

浙江为侨服务全球通平台、浙江省金融综合服务平台、浙江省企业服务综合平台正式开通。 张斌 摄

  目前,浙江有600多万浙商在国内各地经商办企业,有200多万浙商在全球各个国家和地区投资创业。据悉,本届大会由中共浙江省委、浙江省人民政府主办,中共浙江省委统战部、浙江省工商业联合会、浙商总会承办。( 责任编辑查正富 主编陈雪霏)

世界旅游大会“丹寨”成网红

北欧绿色邮报网报道: 11月4日, 2019伦敦世界旅游交易会(WTM London)正式在英国开幕,丹寨万达小镇代表中国贵州参加了本次会议,并获邀在中国展区启动仪式上开展推介。凭借秀丽的山水风景和多彩的民族文化,丹寨万达小镇在本次大会上甫一亮相就成为大会的一个焦点。

  伦敦世界旅游交易会是全球最重要的旅游行业展会之一,至今已有40年历史。

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中国驻英大使为丹寨点赞

  作为本次大会中国国家展区推介活动的重要环节之一,丹寨万达小镇代表中国贵州和丹寨向全球旅游从业者推介了丹寨县各项旅游资源、非遗传统文化和轮值镇长项目。在丹寨现场搭建的展区里,与会者还可以现场体验来自中国的古法造纸、蜡染等丹寨非遗项目。当天同场进行推介的地区还有北京、西藏、河北等地区的代表。

  借助中国贵州于近日登上《孤独星球》2020全球十大最佳旅行地区榜的契机,丹寨万达小镇在现场的推介活动吸引了大量国际与会人士的关注。

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《孤独星球》颁发上榜证书

  作为中国唯一登上2020全球十大最佳旅行地区榜的省份,《孤独星球》还派代表于当天专程来到丹寨发布会,向中国贵州及丹寨颁发了《孤独星球》上榜纪念证书。

  《孤独星球》是一本针对全球背包客撰写的旅行系列丛书,在200个国家和地区销售,年销售量达700万册,约占全球英文旅行指南销售量的四分之一。到2010年,《孤独星球》累计销售突破1亿册,是全球背包客和自助游者海外行必备指南,被国际游客称作“旅行圣经”。10月22日,《孤独星球》在伦敦发布2020年世界最佳旅行目的地,贵州成为中国境内唯一跻身10大世界最佳旅行地区榜单的地区,丹寨万达小镇被当做贵州省主要旅游目的地重点推荐。

  2019伦敦世界旅游交易会官员拉杰·多赫尔(Raj Dohel)也专程赶到丹寨推介会现场祝贺并致辞。他说:丹寨万达小镇项目是一个非常具有创新性的应对贫困的办法,这个项目取得的数据已经非常有力的证明了它的效果,丹寨应该为自己取得的成绩感到骄傲。

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丹寨万达小镇轮值镇长招募受追捧

  拉杰·多赫尔还代表WTM恭喜包括丹寨在内的中国贵州地区登上《孤独星球》2020榜单,并祝愿小镇在本次大会期间开展的轮值镇长全球招募活动取得成功。

  在活动现场,曾担任过丹寨万达小镇第78任轮值镇长的梅根·伊芙斯向全球参会者和媒体推介了丹寨非物质文化遗产、丹寨著名景点,并在WTM推介会现场宣布丹寨万达小镇在全球进行轮值镇长招募。

  此举受到现场人士的追捧,许多外国参会者当场就来到“云上丹寨”展位填写并投递轮值镇长申请表。他们希望可以通过轮值镇长项目帮助更多丹寨民众,并亲身体验《孤独星球》隆重推荐的这一旅游目的地。据统计,在WTM首日,丹寨就已经收到近20份来自海外的申请信。

  一些到场嘉宾表示,丹寨推介会是中国展区首日发布会的亮点,除了因为丹寨获得《孤独星球》的认可,还因为丹寨项目切实帮助了众多当地民众,保护了当地非物质文化遗产。

  现场播放的《村寨故事》视频打动了许多中外观众。来自南非的一位参观者说,在非洲女性作为家里的主要劳动力生活非常艰辛,却得不到应有的尊重。她非常高兴中国有如村寨故事这样的社会企业可以通过万达小镇这个平台帮助丹寨女性获得更好的收入,提升她们在自己社区的地位。她希望万达可以把丹寨扶贫的模式移植到南非,为那里的贫困人口搭建一个平台,帮助当地妇女获得更好的生活。(来源:中新社)

生态环境部:我国臭氧污染以轻度污染为主 可防可控

北欧绿色邮报网援引中新社报道: 生态环境部新闻发言人刘友宾29日表示,从2015年起,全国337个城市1436个点位均开展臭氧监测,数据显示,目前我国臭氧污染虽然有所上升,但以轻度污染为主,总体处于可防可控状态。

 29日上午,生态环境部召开例行新闻发布会,生态环境部新闻发言人刘友宾通报近期重点工作进展情况。

  刘友宾介绍,不久前生态环境部公布了9月和1-9月份全国空气质量,部分地区出现了一些波动。生态环境部组织专家对这些情况进行了认真分析,有以下几个原因:

  首先,受比常年同期偏高气温的影响,全国O3浓度同比上升,优良天数比例同比下降。2019年9月,全国平均气温17.7度,比常年同期偏高1.1度,其中北京、天津、吉林、内蒙古、湖北等省市的平均气温为1961年以来历史同期最高或次高水平。受高温、较强光照影响,日间O3浓度明显上升,导致优良天数比例下降。

  初步分析显示,2019年9月,全国337个地级及以上城市首要污染物为O3(8小时)的天数约占污染天的95%以上、23个重污染天的40%左右,其余重污染天的首要污染物为PM10,说明9月日均空气质量主要受O3浓度影响。全国337个地级及以上城市平均O3浓度为157微克/立方米,同比上升23.6%,优良天数比例同比下降14.7个百分点。

  对流层(近地层)臭氧是一种典型的二次大气污染物,人为排放的极少。地面臭氧主要来源NOx和VOCs在热和太阳光作用下发生的光化学反应。在前体物NOx和VOCs较高的情况下,夏秋季由于温度高、太阳辐射强容易发生臭氧污染。我国标准规定臭氧日最大8小时平均浓度为160微克/立方米,与发达国家基本相当。从2015年起,全国337个城市1436个点位均开展臭氧监测,数据显示,目前我国臭氧污染虽然有所上升,但以轻度污染为主,总体处于可防可控状态。

  其次,降水偏少和气象条件不利,导致颗粒物浓度上升。2019年9月,京津冀地区大气静稳指数同比升高约50%,其中北京市静稳指数同比升高约40%,大气扩散能力明显下降。特别是在2019年9月下旬,京津冀及周边地区出现了持续一周以上的静稳、高湿和逆温天气,导致污染物的持续累积和转化。

  刘友宾介绍,针对上述情况,生态环境部下一步将推动以PM2.5和臭氧协同控制、以NOx和VOCs为重点的多污染物协同减排,积极推进产业、能源、运输和用地结构的优化调整。

  刘友宾秋表示,冬季已来临,气温下降,O3污染水平下降。特别是进入采暖季后各类污染物的排放强度将进一步增加,气象条件转差,PM2.5成为决定环境空气质量的首要污染物。生态环境部将会同有关部门和地方对重点行业采取差异化分级管控等措施积极应对重污染天气,以抵消采暖排放增加和不利气象条件带来的影响。(责任编辑查正富 主编陈雪霏)

阿尔兹海默病新药再引关注 这个疾病你了解多少?

北欧绿色邮报网报道:日前,国外一家生物制药公司宣布,世界首款能改善阿尔兹海默症临床症状的药物,已计划向美国食药品监管局(FDA)提交上市许可申请。据该公司官网公告,若该药物能获准上市,那么它将成为世界上首款能改善阿尔茨海默症临床症状的药物。

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资料图(图文无关)康玉湛摄

  全球超5000万人患阿尔兹海默症

  新药有何疗效?

  当地时间10月22日,美国生物技术公司Biogen(百健)及其合作伙伴日本卫材(Eisai)公开宣布,计划在2020年初向美国食药品监管局(FDA)提交Aducanumab(早期阿尔兹海默症治疗药物)的《生物制剂许可证申请》(BLA)。并表示有望在2年内量产,且将继续与欧洲、日本等国际地区的监管机构进行协商。

  据百健公司公告,若该药物能获准上市,那么它将成为世界上首款能改善阿尔茨海默症临床症状的药物,同时也将证明减少脑内β淀粉样蛋白的积累将有利于阿尔兹海默症临床症状的改善。

  对于该药品的作用,公告中表明:用高剂量Aducanumab治疗的患者认知衰退显著减少,在认知和功能指标,如记忆、定向和语言方面显著获益。患者的个人理财、做家务以及独立外出旅行等日常生活也将获益。

  换言之,若该药物的效果能达到上述预期且获准上市,那么这将为全球5000万家庭带来新希望。

  有数据统计,目前,全球阿尔茨海默症患者至少达5000万人,且呈爆发性增长,预计到2050年将达到1.5亿人。而在中国,阿尔茨海默病患者也已超1000万人,居世界首位,且每年以30万以上的新发病例增长。

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资料图(图文无关)陈建华、薛艳伟供图

  新药申请美国上市

  网友:求不要太贵

  新药计划向美国FDA申请上市的消息,很快传到了中国。消息一经发布,“世界首款阿尔兹海默药被证有效”的话题迅速登上热搜榜第二,并引来网友“围观”:

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网友微博留言截图

  得知新药物或将面世并对阿尔兹海默症有一定改善作用,不少网友表示终于看到了希望,甚至有声音认为,该药物具有“极大的突破意义”,只求药价不要太高。

  对此,百健公司首席执行官Michel Vounatsos也表示:“阿尔茨海默症使全球数以千万计的人受到影响,而今天我们终于获得了突破性的研究结果,这个消息令人振奋。我们希望能为患者提供减缓阿尔茨海默症临床症状的疗法。”

  实际上,在治疗阿尔兹海默症的道路上,中国也从未停止探索的步伐。

  据新京报报道,在2019第四届中国医药创新与投资大会上,绿谷制药已发布中国原创阿尔兹海默症治疗新药GV-971临床III期试验结果,该临床结果证实GV-971(从海藻中提取海洋寡糖类分子)在阿尔茨海默症治疗上的显著作用。

  据报道,该药系中国首个进行大型三期临床试验的抗阿尔茨海默症药物,其上市申请已于2018年11月20日获受理。

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北京老年医院老年认知障碍诊疗中心病房(北京老年医院供图)

  这个疾病你了解多少

  专家:尚无彻底治愈老年痴呆的方法

  丧失语言、遗忘一切,甚至失去自理能力……阿尔兹海默症,像藏在患者脑海中的橡皮擦,几乎抹去了病人所有的认知能力,更让整个家庭都背负起照顾患者的压力之中。

  阿尔兹海默,究竟是一种什么疾病?又是否有治愈的可能?

  对这一疾病的种种问题,北京协和医院神经科主任医师高晶,在一篇科普文章中给出解释。

  高晶解释,阿尔兹海默病,是老年期认知障碍(俗称“痴呆”)分类中的一种,且占主要部分。除阿尔兹海默,“老年痴呆”的分类还包括额颞叶痴呆、血管性痴呆、路易体痴呆等。高晶解释,上述几种痴呆所导致的认知功能退化,均不可逆。

  高晶介绍,目前,医学上尚无彻底治愈老年期痴呆的方法,但早防早治是提高患者晚年生活质量的有效措施。

  高晶解释,医学上仍需增进对痴呆本质的认识,明确治疗靶点。她在文中写道:“中国的相关研究也在进程当中,希望通过脑脊液的生物标记物检测或者淀粉样蛋白、tau蛋白的PET检测等临床实践来帮助更多认知障碍的患者。”

  即便无法治愈,但早起的防治措施却有一定效果。高晶建议,保持健康的饮食、运动及有限的睡眠,对防治痴呆有一定功效。如让老人做一些手部运动,如弹琴、敲键盘、捡豆子等,可有效刺激区域脑血流量。同时,若每天能保持7小时连续睡眠,也对预防和减缓老年痴呆有一定帮助。

  此外,高晶也提出,丰富的生活内容和社交圈子,也能有效刺激大脑皮层。“活到老、学到老”同样可持续锻炼老年人大脑,预防老年痴呆。

  高晶提醒,若家中有老人,一定要对老年的认知障碍做到充分了解,提前预防。一旦发现可疑症状,切勿讳疾忌医,应及时到神经科就诊。(来源:中新社/记者 郎朗 杨雨奇) )

全球变暖正改变北极地貌!冰川融化致5座岛屿浮现

北欧绿色邮报网报道:全球变暖可能正改变北极的地貌!俄罗斯国防部日前表示,俄海军在北极发现了5座新岛屿,正是冰川融化导致了这几座岛屿显露出来。

  俄国防部表示,俄海军在2016年首次利用卫星图像发现了这些岛屿,但只是在近年8月和9月的一次考察中确认并绘制了地图。

  这些新岛屿位于北极Vylki冰川附近,远离遥远的新地马岛群岛海岸,该群岛位于俄罗斯大陆西北的北冰洋。它们的面积从900平方米到54500平方米不等。

  据俄罗斯塔斯社报道,俄探险队队长亚历山大·莫伊斯耶夫22日表示:“基本上,这一发现与冰川融化有关。”“以前这些是冰川,但冰的融化导致了岛屿的出现。”

  俄罗斯国防部称,俄罗斯海军研究人员多年来一直使用卫星数据来研究海岸线的变化。2015年至2018年期间,他们确认了新地岛(Novaya Zemlya)和弗朗茨约瑟夫岛(Franz Josef Land)两个群岛上的30多个新岛屿、海角和海湾。

  科学家们警告说,新出现的岛屿不是“意外”,而是北极冰川和海冰大规模融化导致的日益严重的气候危机的直接结果。

  据悉,北极的升温速度是全球平均水平的两倍,由此导致的冰川融化可能会破坏生命周期,并威胁到全球各地人们的生命。(来源:中新社)

美团携手世界粮食计划署共推“拒绝隐性饥饿”行动

北欧绿色邮报网援引中新社报道: 10月16日世界粮食日,在“行动造就未来-健康饮食实现零饥饿”的全球主题下,美团与联合国世界粮食计划署共推“拒绝隐性饥饿”健康饮食倡导行动,联动明星、新浪微公益,及美团点评平台上超五十家餐饮连锁品牌,通过理念倡导及多种行动举措,聚焦“隐性饥饿”问题,推动全球“零饥饿”的可持续发展目标实现。

  据数据显示,全球已有超20亿人处于“隐性饥饿”。中国农业农村部食物与营养发展研究所唐振闯博士说:“隐性饥饿一般因人体维生素和矿物质缺乏造成,它与显性饥饿( 能量、蛋白质、脂肪等宏量营养供应不足)相比,更加隐蔽,也更难察觉,长期处于‘隐性饥饿’可能导致婴儿出生缺陷、发育不良,增加儿童和孕产妇死亡率及免疫系统弱化等诸多疾病,严重危害身体健康。”

  世界粮食计划署驻华代表屈四喜表示:“联合国可持续发展‘零饥饿’的目标除了要在2030年消除饥饿,还要消除一切形式的营养不良。世界粮食计划署和美团的携手合作正是为了实现这个目标,为此双方不断探索新的合作模式和方法。今年的活动不仅契合世界粮食日的主题,而且准确传达了‘零饥饿’中营养的理念,‘饥饿餐厅’的创意既有新意,又能让民众直接体会健康饮食的重要性。”

  向用户传递均衡的膳食理念,推动膳食源头供给改善,保障用户膳食更丰富,营养多选择,是解决隐性饥饿行动的重要环节。为此,美团通过旗下美团、大众点评、美团外卖三大核心平台的连接能力,携手世界粮食计划署、名人合作伙伴周冬雨、陈赫、杜江发起联合倡导,通过提升用户膳食理念,拒绝隐性饥饿。活动采取线上线下联动的形式,线上联合新浪微公益发起“吃彩虹挑战”的公众意识提升活动,线下联合外婆家、GAGA鲜语、新元素三家餐饮品牌,在上海同时落地 “饥饿餐厅”快闪店,向消费者直观展示“隐性饥饿”的成因及危害,引导消费者对膳食营养的关注。同时,大董、西贝莜面村、全聚德、云海肴、羲和雅苑、点都德、胖哥俩、吉祥馄饨、香守花胶鸡海鲜火锅等超五十家餐饮品牌,在农业农村部食物与营养发展研究所的指导下,推出“吃出彩虹公益套餐”,通过关注套餐食材多样,保障膳食搭配更丰富。美团外卖发挥业务优势,通过发布《中国轻食外卖消费报告》等形式,为消费者提供一份健康餐饮选择指南,保障营养更多选择。

  对于本次行动,美团联合创始人穆荣均表示:“作为一家以‘吃’为核心的生活服务平台,美团一直致力于实现‘帮大家吃得更好,生活更好’的公司使命,发挥平台影响力,引导用户健康生活、绿色消费,带动商家提供更多健康、绿色的供给,丰富人们的生活方式和选择。此次与世界粮食计划署共推‘拒绝隐性饥饿’理念,是呼应联合国‘零饥饿’发展目标,同时也希望以此提升更多美团生态相关方对营养均衡,健康生活理念的关注和实践。”

  与此同时,在拒绝隐性饥饿的过程中,美团与世界粮食计划署始终关注贫困地区学龄前儿童营养改善,本次商家推出的“吃出彩虹公益套餐”,通过美团每完成一笔销售,商家都将向世界粮食计划署“学龄前儿童营养餐”公益项目捐赠一笔善款,而美团公益也将发挥自身平台优势,推动更多爱心网友关注并支持该项目,多方努力让孩子们吃得更好,健康成长。(责任编辑查正富 主编陈雪霏)

国际货币基金组织:对抗气候变迁 碳税是最强效方法

北欧绿色邮报网援引中新社据“中央社”报道:当地时间10日,国际货币基金(IMF)表示,全球的碳排污染大户国家应该一起同意课征碳税,未来十年每吨碳排征收75美元税金,让气候变迁维持在安全水平。对抗气候变迁,碳税是最强效方法。

  据报道,IMF呼吁即刻采取行动应对气候变迁,但近年来,主要经济体在对抗灾难性全球暖化的预防上意见不一致,导致政策扞格。

  IMF研究人员表示:“碳税是最强而有力且有效的工具,但前提是以公平、增进友好的方式实施。”

  2018年爆发“黄背心”示威并多次暴力流血后,法国政府因而暂缓把碳税提高至每吨50美元以上的计划。同时,美国总统特朗普宣布,将退出2015年签署的《巴黎气候协议》。

  据报道,这份报告赶在IMF和世界银行下周举行年度会议前公布,IMF新任总裁格奥尔基耶娃料将于会上,敦促会员国对气候变迁采取行动。

  根据IMF10日公布的这份研究报告内容,要防止全球气温较工业革命前升温超过2摄氏度,以达成《巴黎气候协议》目标,碳税是最有效的方法。加征碳税会提高电力、旅游、制造、运输和食品等碳排密集产业的成本。

  报道称,目前,全球平均的排放碳价为每吨2美元,想要达成《巴黎气候协议》目标,需由20国集团(G20)里的碳排大户集体在2030年之前把碳税提高至每吨75美元,才有可能实现。

  这份报告表示,对所有国家课征碳税可避免让没有缴税的国家“搭便车”,并让真正实施改革国家的产业能与其他国家竞争。

  但IMF研究人员承认,此举将造成令人却步、不均等的代价。调高碳税至每吨75美元,将使煤炭价格超过现有的3倍。加拿大电力价格将迅速上升超过30%,澳大利亚电价飙涨70%至90%。根据这份报告内容,大部分国家汽油价格将上涨5%至15%。(责任编辑查正富 主编陈雪霏)

中国科学家研制出微型“血栓探测器”

北欧绿色邮报网援引中新社据新华社消息(记者 陈席元)报道:把一块特殊的生物材料,制成仅有正常血管十分之一厚的柔性传感器,将其贴在血管或心脏周围,就可在体外设备清晰记录血栓形成初期、中期和末期全身血压的细微变化,精准确定血栓位置。

  记者11日从南京理工大学获悉,该校化工学院冯章启教授课题组原创的这项技术取得阶段性突破,并已完成动物临床医学评价,相关成果近日发表在《美国化学学会·纳米》(ACS Nano)上。

  心血管疾病是人类健康的主要威胁之一,对这类疾病进行预测与术后跟踪,是临床有效诊疗的关键。然而,目前各类分子筛查和影像学技术仍缺乏精准识别功能,冯章启课题组的新技术就试图破解这一难题。

  据论文第一作者李通博士介绍,课题组长期研究生物电子材料与纳米器件,此次他们采用一种厚度仅有200微米的高效柔性纳米纤维材料,它能够精确感受压强变化,再以电压形式表现出来。

  同时,这种材料具有优异的稳定性、敏感性以及生物相容性,课题组用它设计制造了一种柔性植入式压力传感器,并在动物实验中将传感器植入到成年猪的外周血管和心脏部位,获得了实时、精准的血压变化信号。

  “未来,这种柔性传感器可以在心血管手术时植入病人体内,通过无线信号发射器,病人和医护人员在手机端就能实时了解心血管系统的病变情况。”冯章启说,此外,这种精准“压力计”还可用于脑颅压、肾脏压、眼压等领域。(责任编辑查正富 主编陈雪霏)