STOCKHOLM, May 10, (Greenpost) — Swedish Radio and Aftonbladet reported on May 6 that Swedish Customs had tested the Chinese traditional herb content medicine Lianhuaqingwen which they confiscated and gave a conclusion that the medicine doesn’t function and only contains mint in it.
This report was spread to China and Chinese medical academicians and relevant organisations immediately reacted on this news saying that the Swedish conclusion was not right.
The news said Swedish official in Drugs Administration lab said he didn’t find enough evidence to show the medicine is useful because he only found mint in it, but didn’t mention anything else and claimed that there was no any relevant articles about it.
This conclusion shows that he didn’t find the article about Lianhuaqingwen, nor read it. He neither found nothing else in the medicine or he found something but he didn’t know what they were.
News from Chinese Dr. Li said in fact there were 13 ingredients or components in the medicine. But only mint has a well recognised chemical format while the other Chinese herbs didn’t have chemical format.
The 13 ingredients are Lianqiao which is Forsythoside E, Jinyinhua which is honeysukle, similar to dandelion, luding, Rutin, mahuang, dahuang, which is Epherdra, bitter apricot core, plaster, banlangen which is a well-known antivirus medicine in China. Banlangen was invented in mid 1990s. I remember once I was asked to translate the specifications of the medicine because my radio people were often asked to do this kind of translation job. But I refused to do it because I felt I knew so little about medicine knowledge. But over the years Banlangen has become a daily medicine like Alvedon in Sweden. If people have virus type of flu, people can take Banlangen. If they have bacteria type of cold, they can just take the ganmaochonji a kind of small particle type of powder and just putting it into a cup of hot water and drink it.
Mianmaguanzhong, I do not know what it is, but Yuxingcao is also a well known name in dealing with eyes, Huoxiang is also a very common but well effective Chinese medicine. Hongjingtian is produced in Tibet and famous for its function to help you to have enough oxegon. When we were in Tibet, a colleague felt he was lack of oxegon, he went to buy oxegon bottle and Hongjingtian. Gancao was also a Chinese medicine both in tablet form or in raw herb form. One can swallow tablet, but drink water which soaks the gancao herb. The last one is exactly mint.
Mint is indeed a good component for various kinds of Chinese medicine. Mint sugar in Lidl actually helps you if you have a sore throat.
Academician Zhong Nanshan who was the key person in leading the campaign against Covid-19. President Xi Jinping was leading the campaign by sending hospitals, doctors and nurses and all the supplies through various provinces, Zhong Nanshan was a symbol of technical part, a lot of information was sent out through Zhongs name. Academician Zhang Boli who has retired at home, but he was summoned to lead in the campaign with his rich Chinese medicine knowledge. They both are authoritative while Zhong was in western medicine and Zhang was in Chinese medicine. But both recommended Lianhuaqingwen. During China’s campaign against covid-19, it was a perfect example of cooperation and combination of Chinese and western medicines.
Let’s look at the corona virus again. It is a virus, but the symptom when people catch it is coughing, fever, running or drying nose and fatigue. Thus the symptom is similar to a serious cold. Only when people are either too weak or too healthy to fight against the virus with no strength or too much strength, fiercely, then it hurt your organs especially the lung. The most typical symptom in the end is respiratory problem. But at the beginning, you just got a cold.
And all these components or ingredients of Lianhuaqingwen are useful in fighting against cold. Thus it can almost be treated as a most powerful kind of medicine in treating cold.
According to a joint study by researchers in Nanjing Chinese Medicine University and Shanghai Drug Research Institute under the Chinese Academy of Sciences, Lianhuaqingwen is so far the most functional medicine in inhibiting corona virus from reproduction and curing the fever of the patients.
Fang was in charge of a unit which had 108 patients who had light symptoms. He found that the patients had one unified symptom, that was panic and fear, worries and weak nerves. After trying western medicine for one week, he found it not only did not give positive results but give negative effects on liver. Thus he prescribed all the time Chinese medicine after a week. The Chinese medicine mainly calmed down the patients, relieved them from panic feelings and got them sleep better.
As a result, no one became more serious and no death happened in his unit. In comparison, those who were treated with western way or medicine, a lot of them could become worse and were sent to ICU.
According to the research paper, Lianhuaqingwen was used for severe patients too and by alleviating their fever or other symptoms, lives were rescued.
But so far, experts admit that there were no cure all kind of medicine against covid-19. But as a supportive medicine or healthy product, those who are confirmed to get covid-19 positive, they can take Lianhuaqingwen. Whether it works or not, one can feel it after three days. If after three days it did not function, you feel worse, then you must call the doctor again.
Sweden has tried its best to deal with the covid-19 and avoided the problem China had at the beginning of getting the hospital too crowded and almost collapse. Sweden wanted to let the covid-19 happen slowly, which is a good idea.
However, the virus loves people and can quickly spread from one person to two persons if you have close contacts, for example in crowds, not necessarily to kiss each other. It can spread through spit and sneeze or cough. But if people keep themselves isolated, the virus couldn’t find another person to reproduce itself, it will die with the recovery of the person. Thus isolation is very very important.
The earlier, quicker to isolate, the better. For example, if Swedish cancelled the travel, canceled the Eurovision, canceled the birthday party, and isolated quicker and earlier in other areas where you just found a couple of cases, then the virus probably got wiped out by now. But no one knows. Maybe it would take two to three months any way.
Thanks to Swedish people who are good at keeping social distance and mostly follow the government instructions, Swedish people did not sacrifice too much freedom and the society continues to function, which can be seen as a positive aspect. But if people especially those who got infected, but not to the extend to go to hospitals intensive care, maybe if they take the Lianhuaqingwen, it can not only comfort them, but also prevent them from getting worse.
To say it just got mint in it and does not function, it sounds like it is just the mint candy. But it is simply not true.
In fact, Lianhuaqingwen was just one of the Chinese medicines that dealt with covid-19. I guess it became famous because of its mass production and packaging. Qingfei Paidu Tang or Lung cleaning and poison eradicating syrup was also very popular during covid 19 campaign in Wuhan, Central China. But this kind of medicine is pure herb and needs to be boiled each time for each person. It is hard to get mass production. Chinese doctors also stressed that it was one person with his or her own prescription according to his or her own symptom.
Chinese medicine does not stress killing the virus or fighting the virus, instead, it stressed that the medicine helps patients to get stronger in immune system and physical strength by getting rid of or alleviating the symptom.
Covid-19 is indeed a strong virus which is very hard to deal with because it reproduces itself so quickly once it entered humans body and attacked the lung. By fighting back with the immune system, patients other organs such as liver or heart or kidney could be damaged too. That was why a lot of people died of not only virus, but also several other combined diseases. The virus can damage your immune system. Thus, the Chinese doctors emphasized that people should eat enough protein and sleep well. Getting yourself strong is the key to deal with the covid 19.
The following is the research paper about Lianhuaqingwen.
Lianhuaqingwen (LH) as traditional Chinese medicine (TCM) formula has been used to treat influenza and exerted broad-spectrum antiviral effects on a series of influenza viruses and immune regulatory effects . The goal of this study is to demonstrate the antiviral activity of LH against the novel SARS-CoV-2 virus and its potential effect in regulating host immune response.
The antiviral activity of LH against SARS-CoV-2 was assessed in Vero E6 cells using CPE and plaque reduction assay. The effect of LH on virion morphology was visualized under transmission electron microscope. Pro-inflammatory cytokine expression levels upon SARS-CoV-2 infection in Huh-7 cells were measured by real-time quantitative PCR assays.
LH significantly inhibited SARS-CoV-2 replication in Vero E6 cells and markedly reduced pro-inflammatory cytokines (TNF-α, IL-6, CCL-2/MCP-1 and CXCL-10/IP-10) production at the mRNA levels. Furthermore, LH treatment resulted in abnormal particle morphology of virion in cells.
LH significantly inhibits the SARS-COV-2 replication, affects virus morphology and exerts anti-inflammatory activity in vitro. These findings indicate that LH protects against the virus attack, making its use a novel strategy for controlling the COVID-19 disease.
Coronaviruses are a group of enveloped viruses named for their coronary appearance with positive single-stranded RNA genomes . In addition to six known strains of coronaviruses that are infectious to humans, a novel coronavirus (SARS-CoV-2) was detected recently in Wuhan, China [3,4]. Like the other two highly pathogenic coronaviruses SARS-CoV and MERS-CoV, SARS-CoV-2 also caused severe respiratory illness and even death. Moreover, the population’s susceptibility to these highly pathogenic coronaviruses has contributed to large outbreaks and evolved into the public health events, highlighting the necessity to prepare for future reemergence or the novel emerging viruses .
Similar to SARS-CoV and MERS-CoV, SARS-CoV-2 is initiated by zoonotic transmission likely from bats and spreads rapidly among humans . The basic reproduction number (R0) of person-to-person spread is about at 2.6, which means that the SARS-CoV-2 infected cases grow at an exponential rate. As of February 07, 2020, 57,620 cases of the SARS-CoV-2 have been reported in China, including 26,359 suspected cases, and a sustained increase is predictable. The initial patient cluster with confirmed SARS-CoV-2 infection was reported Wuhan pneumonia with unknown aetiology, which bore some resemblance to SARS-CoV and MERS-CoV infections and was associated with ICU admission and high mortality. Moreover, High concentrations of cytokines were recorded in plasma of patients requiring ICU admission, such as GCSF, IP10, MCP1, MIP1A, and TNFα, suggesting that the cytokine storm was associated with disease severity . A retrospective clinical study indicated the risk of fatality among hospitalized cases at 4.3% in single-center case series of 138 hospitalized patients , and the infection fatality risk could be below 1% or even below 0.1% in a large number of undetected relatively mild infections . However, It is challenging to judge the severity and predict the consequences with the information available so far. Since no specific antiviral treatment for COVID-19 is currently available, supportive cares, including symptomatic controls and prevention of complications remain the most critical therapeutic regimens, especially in preventing acute respiratory distress syndrome . Although the control of SARS-CoV-2 still presents multiple challenges in the short term, more potent antiviral drugs are urgent to be developed .
At present, some drugs are effective in eliminating SARS-CoV-2 and improving symptoms. The most promising antiviral drug for SARS-CoV-2 is remdesivir that is currently under clinical development for the treatment of Ebola virus infection . However, the efficacy and safety of remdesivir for SARS-CoV-2 pneumonia patients need to be assessed by further clinical trials. In addition, in the prevention and treatment of COVID-19, Tranditonal Chinese medicines have received broad adoption, especially in treating cases of mild symptoms . Lianhuaqingwen (LH), a Chinese patent medicine composed of 13 herbs, has played a positive role in the treatment of SARS-CoV-2. A retrospective analysis of clinical records was conducted in the SARS-CoV-2 infected patients at Wuhan Ninth Hospital and CR & WISCO General Hospital. LH combination could significantly relieve cardinal symptoms and reduce the course of the COVID-19 , making it successively included in the Guideline for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Pneumonia (On Trials, the Fourth/Fifth/Sixth/Seventh Edition) issued by National Health Commission of the People’s Republic of China and also recommended by 20 provincial health commissions including Hubei, Beijing, and Shanghai as well as National Administration of Traditional Chinese Medicine for the treatment of COVID-19. Moreover, LH exerted broad-spectrum effects on a series of influenza viruses by inhibiting viral propagation and regulating immune function and achieved similar therapeutic effectiveness with Oseltamivir in reducing the course of H1N1 virus infection [1,14,15]. Notably, the anti-influenza activity of LH in infected mice might depend on the regulation of cytokines, particularly in cytokine storm associated cytokines, such as IP-10, MCP-1, MIP1A, and TNF-α . In the present study, we evaluated the antiviral and anti-inflammatory efficiency of LH against a clinical isolate of SARS-CoV-2 from Guangzhou in vitro.
2. Materials and Methods
2.1. Cell lines and virus
The African green monkey kidney epithelial (Vero E6) cells and the human hepatocellular carcinoma (Huh-7) cells were cultured in Dulbecco’s Modified Eagle’s medium (DMEM, Gibco, USA) supplemented with 10% fetal bovine serum (FBS) at 37 °C. A clinical isolated SARS-CoV-2 virus (Genebank accession no. MT123290.1) was propagated in Vero E6 cells, and viral titer was determined by 50% tissue culture infective dose (TCID50) according to the cytopathic effect by use of Reed-Muench method . All the infection experiments were performed in a biosafety level-3 (BLS-3) laboratory.
2.2. Reagent preparation
LH capsule (Lot No.A2001108) was obtained from Yiling Pharmaceutical Co. Ltd. (Shijiazhuang, China). UPLC fingerprints of LH consist of 32 common peaks. 9 of 32 common peaks are identified. The similarities in 10 batches of LH Capsules samples were all above 0.96 (Supplementary Fig. 1). The black powder of raw material of LH was first dissolved in dimethyl sulfoxide (DMSO) to 240 mg/mL. After shaking for 30 min at room temperature, the LH solution was diluted with serum-free DMEM to 24 mg/mL as a stock solution and stored at −20 °C before using. Remdesivir was kindly provided by Prof. Jiancun Zhang from Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences and was dissolved in DMSO to 100 mM and stored at −20 °C before using. DMEM with 2% FBS was used as the dilution buffer in the follow-up experiments.
2.3. Cytotoxicity assay
The cytotoxic effects of the LH on Vero E6 and Huh-7 cells were evaluated by Methyl Thiazolyl Tetrazolium (MTT) assay. Briefly, monolayers of Vero E6 cells and Huh-7 cells in 96-well plates were rinsed with phosphate-buffered saline (PBS) followed by incubation with indicated concentrations of LH. After 72 h, the cells were stained with MTT solution at 0.5 mg/mL for 4 h. The supernatants were then removed, and the formed formazan crystals were dissolved in 200 μL DMSO. The absorbance was measured at 490 nm using Multiskan Spectrum reader (Thermo Fisher, USA). The 50% cytotoxic concentration (CC50) was calculated by the GraphPad Prism 7.0 software.
2.4. Cytopathic effect (CPE) inhibition assay
The Vero E6 cell monolayers were grown in 96-well plates and inoculated with 100 TCID50 of coronavirus strains at 37 ̊C for 2 h. The inoculum was removed, and the cells were subsequently incubated with indicated concentrations of LH or the positive control remdesivir. Following the 72 h of incubation, the infected cells shown 100% CPE under the microscope. The percentage of CPE in LH-treated cells were recorded. The 50% inhibition concentration (IC50) of the virus-induced CPE by LH was calculated by the Reed-Muench method .
2.5. Plaque reduction assay
The Vero E6 cell monolayers in 6-well plates were infected with 50 plaque-forming units (PFU) of SARS-CoV-2 for 2 h at 37 °C. After incubation, the cell monolayers were covered with agar overlay (final concentration: 0.6% agar, 2% FBS, indicated concentrations of LH or remdesivir). The plates were then incubated for 48 h at 37 °C with 5% CO2. Subsequently, the agar overlays were removed, and the cell monolayer was fixed with 10% formalin, stained with 1% crystal violet, and then the plaques were counted and photographed.
2.6. RNA isolation and reverse transcriptase-quantitative PCR analysis (RT-qPCR)
The Huh-7 cell monolayers in 12-well plate were rinsed with PBS and then exposed to coronavirus at a multiplicity of infection (MOI) of 1 for 2 h at 37 °C. The inoculum was removed and replaced with the indicated concentrations of LH or mock-treated with DMEM supplemented with 2% FBS for subsequent 48 h incubation at 37 °C with 5% CO2. The cells were then harvested for RNA isolation and qPCR as described previously . The primer and probe sequences used for analysis are listed in Supplementary Table 1. The relative mRNA expression was calculated using the 2-△△Ct method with GAPDH as an internal reference gene.
2.7. Electron microscope
Monolayers of Vero E6 cells in 6-well plates were incubated with SARS-CoV-2 at a MOI of 0.001 for 2 h at 37 °C. The virus inoculum was then removed and replaced with DMEM medium supplemented with 2% FBS containing LH (600 μg/mL) or remdesivir (5 μM). At 48 h p.i., the cells were fixed, dehydrated and embedded as described previously . Ultrathin sections (70 nm) of embedded cells were prepared, deposited onto Formvar-coated copper grids (200 mesh), stained with uranyl acetate and lead citrate, and then observed under JEM-1400 PLUS transmission electron microscopy (Japan Electron Optics Laboratory Co., Ltd., JEM-1400 PLUS).
2.8. Statistical Analyses
Statistical analysis was performed using GraphPad Prism 7.0 software. The differences in mRNA expression levels of cytokines were compared using a one-way analysis of variance (ANOVA). Values of p < 0.05 was considered to be statistically significant.
3.1. Antiviral activity of LH on SARS-CoV-2 in vitro
The cell viability after LH or remdesivir treatment was determined by MTT assay in both Vero E6 and Huh-7 cells. LH showed unapparent cytotoxicity for both cell lines at concentrations up to 600 μg/mL (Fig. 1A, C). The positive control remdesivir showed no cytotoxicity to cells at a concentration of 50µM (Fig. 1B, D).
To investigate the antiviral effect of LH against SARS-CoV-2 virus, the Vero E6 cells were infected with 100 TCID50 of virus and incubated with LH at various concentrations for 72 h. As shown in Fig. 2A, LH inhibited the replication of SARS-CoV-2 virus with an IC50 value of 411.2 µg/mL by CPE assay (Fig. 2A). Meanwhile, treatment with LH following infection also had a dose-dependent inhibitory effect on plaque formation of the SARS-CoV-2 virus (Fig. 2C). We selected remdesivir as the positive control in our study and the results showed that remdesivir potently inhibited virus-induced CPE with an IC50 of 0.651 µM and a total plaque formation inhibition at 5 μM (Fig. 2B, C).
To further confirm the efficacy of LH in inhibiting SARS-CoV-2 virus replication in cells, we detected the viral particles in ultrathin sections of infected cells under electron microscopy. At 48 h p.i., viral particles were found in cytoplasm, intracellular vesicles, endoplasmic reticulum, and cell membrane and presented spherical crown-like appearance, which was typical coronavirus morphology (Fig. 3B, G). LH (600 μg/mL) and positive control remdesivir (5 μM) treatment resulted in a reduction of the number of virions compared with mock-treated infected cells (Fig. 3G–J). It was interesting to note that some virions in the surface of LH-treated cells presented spindle sharp which was in contrast to the typical spherical particles in the mock-treated cells (Fig. 3I).
3.2. Inhibition of SARS-CoV-2-induced cytokine and chemokine expression by LH in vitro
To determine the effect of LH on the expression of cytokines and chemokines induced by SAR2-CoV-2, the mRNA expression levels of TNF-α, IL-6, CCL-2/MCP-1, and CXCL-10/IP-10 were detected and compared between the LH-treated and mock-treated Huh-7 cells. The results showed that the elevated expressions of these four cytokines were significantly inhibited by LH treatment in a concentration-dependent manner (Fig. 4).
Starting from December 2019, a pandemic of respiratory illness caused by a novel coronavirus named SARS-CoV-2 is sweeping the mainland of China. This virus has spread to several foreign countries, threatening to trigger a global outbreak. Several antiviral agents can be envisaged to control or prevent viral infections by antiviral assay in vitro [14,17]. However, the efficacy and safety of novel candidates need validations in vivo, even for those clinically approved medicines, which means that it will take months to years for clinical practices. At present, symptomatic and supportive treatments remain key to clinical practices. Thus, Traditional Chinese Medicines (TCM) carried both the antiviral effect and the symptomatic relief might bring more clinical benefits . As a classical TCM prescription for respiratory diseases, LH is the only approved medicine in the treatment of SARS and influenza. After the outbreak of SARS-CoV-2, LH as a representative TCM prescription was recommended again in the latest Guideline for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Pneumonia issued by National Health Commission of the People’s Republic of China The purpose of this study was to demonstrate whether the therapeutic effects of LH on the COVID-19 targeting virus replication and immunological regulation as it did on the infection caused by influenza viruses.
Our previous study showed that LH exhibited in vitro anti-influenza activity with IC50 ranging from 200-2000 μg/mL . Here we demonstrated that LH also has a comparable antiviral potency against the SARS-CoV-2 virus with an IC50 value of 411.2 μg/mL (Fig. 2). Transmission electron microscopy (TEM) has been a potent tool to observe virus entry, virus particle assembly, viral ultrastructure, and budding from the plasma membrane . To understand the antiviral details of LH, EM pictures were taken from each group. Abundant virus particles assembled at the surface of membrane, cytoplasm, and plasma vesicles in the SARS-CoV-2 infected cells, decreased in the treatment of LH at 600ug/mL. Notably, slight deformation of virus particles was seen in the LH treatment, which required us to make further studies.
Highly pathogenic coronaviruses such as SARS-CoV and MERS-CoV cause fatal pneumonia, which is mainly associated with rapid virus replication, massive inflammatory cell infiltration and elevated proinflammatory cytokine/chemokine responses. Although the pathophysiology of fatal pneumonia caused by highly pathogenic coronaviruses has not been completely understood, accumulating evidence suggests that the cytokine storm plays a crucial role in causing fatal pneumonia . Excessive amounts of proinflammatory cytokines were reported (e.g., IL-1β, IL-6, IL-12, IFN-γ, IP-10, and MCP-1) in the serum of SARS patients , similar in the serum of MERS patients . Chaolin Huang et al. confirmed the occurrence of the cytokine storm in the COVID-19 patients in ICU rather than those in non-ICU patients . Based on the excessive cytokines responses, Suxin Wan et al. claimed that IL-6 and IL-10 levels could be used as one of the bases for predicting the outcome and prognosis of the COVID-2019 . In this study, host cells infected with HCoV-229E and SARS-COV-2 increased the cytokine release such as TNF-α, IL-6, CCL-2/MCP-1, and CXCL-10/IP-10, which was suppressed by LH in a dose-dependent manner. The change of cytokine profiles suggested that LH might have a potential effect on the inhibition of cytokine storm induced by SARS-COV-2, which also needed to be validated in vivo.
Since the launch of LH, it has been widely used as a broad spectrum of antiviral agent in the clinical practice, especially for various respiratory virus infections. Previous studies have shown that LH a broad spectrum of effects on a series of influenza viruses by interfering with both viral and host reactions. Although LH significantly relieved the clinical symptoms of the COVID-19, the underlying mechanism of antiviral effects on coronavirus, especially in the SARS-COV-2, was still elusive. In this study, we demonstrated that LH exerted its anti-coronavirus activity by inhibiting virus replication and reducing the cytokine release from host cells, which supported the clinical application of LH in combination with existing therapies to treat COVID-2019.
The study was funded by Beijing Municipal Science and Technology Commission NCP Emergency Project; Hebei Provincial Department of Science and Technology NCP prevention and control emergency scientific research project (Grant no. 20277708D); The Science research project of the Guangdong Province (Grant no. 2020B111110001); Daxing District Science and technology development projects (Grant no. KT202008013).
Appendix A. Supplementary data
Download all supplementary files included with this articleHelp
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Stockholm, Feb. 22(Greenpost) — Today a news was spreading around the wechat circle. That was Academician Zhong Nanshan smiled. Dr. Zhong was considered as a hero in anti-SARS campaign in 2003 because he was one of the first who declared this was a serious epidemic and caused attention from the government.
Dr. Zhong Nanshan Smiles
This time Dr. Zhong was also the most authoritative voice saying that the corona virus could spread from person to person and at a faster speed.
When he was interviewed before, he was very serious and looked a bit tired and stressed. He almost cried when he was interviewed for the first time when he mentioned that Wuhan people sang the national song through the windows in the evening after the order was issued that Wuhan city was closed and all the people should stay at home.
It was indeed very moving and respectful for Wuhan people because in front of the sudden attack of the virus and the determined order of closing a city which has a population of 14 million. It was not an easy decision because even after the decision, Wuhan Mayor Zhou Xingwang was still saying that this was historic and if anything wrong with it, he would like to shoulder the responsibility.
Some people thought he should have closed Wuhan even earlier, but it is indeed understandable that the decision needed scientific evaluation which took time and efforts.
Dr. Zhong was 84 years old and he was very respectful. Both leaders and people really listen to him and thus a lot of notices were issued or advised with his name. But when mentioned Dr. Li Wenliang who first issued the news in his Wechat circle among friends and colleagues but got infected and died at age of 34, Dr. Zhong said Li was a hero and he should be respected too. At that moment, tears also sheded from his eyes.
But yesterday at a press conference in Guangzhou, he took off his mask and smiled. This smile implied a relief that the COVID-19 had been under control. The newly infected cases have decreased for a consecutive 16 days outside Hubei province. He did not say the turning point has come. He said Wuhan is still the heavily infected area. But the trend is in positive direction.
According to news from CDC China the newly diagnosed cases reached to 397 while the new death cases reached to 109 with accumulated cases reaching to 76288 and death toll 2345 and recovered cases 20659. Recovered number goes beyond 20 thousand.
Yesterday they also lifted observation for 26441 people. Accumulated close contacts were 618915 people and 113564 of them are still on observation.
Hubei has 366 newly diagnosed infected cases while 1767 cases were recovered yesterday. 106 people including 90 from Wuhan died. Total death accumulated to 2345 people.
47647 people in Hubei have been identified as infected and Hubei’s beds in hospital also almost reached 40 thousand. Thus those who are in need can possibly get a bed. 10892 people are severely infected. 13557 people have recovered and left hospital so far in Hubei province.
During the campaign against the COVID-19, Chinese medicine exerted a great role. Dr. Zhong Nanshan said Chinese medicine can exert a role in alleviating the symptom.
Many Chinese medicine doctors used many kinds of herbal medicine to clear the lung and improve the immune system so that the patients can have more strength to fight against the virus.
The theory is that Chinese medicine is used to improve patients’ immune systems while the western medicine theory is to combat the virus and reduce infections but the side effect is very serious.
Chinese medicine doctors even teach the patients to play Baduanjin, a kind of Taiji exercise. They treat each patient with personal treatment and the result was quite good. The Chinese medicine is used to treat the light infected patients and prevented them from getting worse.
China’s control of the COVID-19 is seen as effective because it avoided large scale infection around the world. By closing down the big city and controlling spread of virus, many people believe this could only be done in China under the leadership of the CPC. Chinese government under the leadership of President Xi and CPC have taken stronger measures to control the spreading with the leading role played by respected doctors and nurses and party members.
China has exerted its advantage and tradition of helping each other among all provinces, for example 16 provinces provided help with their capacity to Hubei province and overseas Chinese also gave donations of masks from the beginning to Hubei provinces hospitals. Two years ago when I was in Xinjiang, they said they were grateful for 19 brotherly provinces to support them. Now when Hubei suffers from COVID-19, sister areas in Xinjiang donated a lot of apples to Hubei showing the Chinese culture of helping each other when in need.
It is worthwhile to mention that there was one city in Hubei province closed its city a week earlier and the infection was substantially reduced. Sichuan province and Henan Province were also very strict in preventing the virus from spreading and very effective.
Zhejiang province got second most infections since it has close relations with Hubei province. But Zhejiang province took even more strict measures in controlling the spreading of the virus and put it under control sooner.
So far, many provinces have resumed production and workers in western China were sent back to eastern regions with chartered airplanes or chartered fast trains since the traffic became rare during the Chinese Spring Festival.
Many Chinese said this spring festival was very special, but it was also normal because this year all the families must stay at home and children don’t need to go back to school so soon.
Many feel panic and worried while many others use the chance to study or do something more interesting in addition to dance and exercise at home.
With Wechat, people can share information and encourage each other or help each other.
Chinese humor also appeared during the anti virus campaign. For example love was sent through the message and the answer can be “lets not meet now.”
One of humor was very interesting and here I translated it as the following:
Wuhan has made eight contributions to the world:
Hong Kong demonstrators stopped demonstration.
Macaos casino was closed for the first time in history.
60 weeks demonstration in France stopped due to a woman from Wuhan arriving there.
Middle East war fairs are somewhat decreasing.
All the outside school courses have stopped. Education ministry could not stop it, but Wuhan did it.
The large scale eating and drinking life style stopped overnight. Even Chinese disciplinary committee could not stop it before.
Most of the Chinese families became united and harmonious because the husband and wife have to be at home day and night.
During these days, even the thieves stopped stealing because if they go to the street, there are no people and if they visit homes, all family members are there.
In addition, writers, artists and educators are also working at home. Many teachers began online teaching or live broadcast. Many home business started and many innovative ideas came out and actions taken at home with internet.
During the campaign, postmen were very busy and they job quardruppled. Many restaurants were severely affected, but the fast food somewhat better survived.
During the first week people relied on their stored food for the week long spring festival. But after two weeks, people have to go out to buy food and in some area, the practice was that every three days one family can send out one person to buy all the groceries.
The market supply is still there and many provinces donated things they have such as vegetables, apples, cabbage and rice. At beginning, Wuhan gave the vegetables to the market, but after the donor questioned about it, people stopped that action, but it also appeared that the vegetables got rotten because short of personnel to deliver it. Thus, I think it is not a bad idea to send these vegetables to the market sellers either donate or with low cost. Because it is hard for the Red Cross to redistribute these vegetables to every family or hospital or other units. Let market function is not a bad idea.
During the first week, it was somewhat panic because all over the world, the overseas Chinese said they donated goods, but due to the closedown of traffic and many countries stopped airlines, it took longer time for the good to arrive in Wuhan or Hubei, some took two or three weeks.
Due to the panic mentality, there have been some episodes of the news or communication driven by social media to lead to people’s sadness such as Dr. Li Wenliang’s death, the poetic and friendship words on donation packages from Japan aroused a big discussion. Some people said the Japanese are more educated than Chinese who only know to say Cheer up Hubei, Wuhan, or God Bless China. But as more patients were cured and more hospitals were built, the desperate mentality has been cured.
At the very beginning, China also stunned the world by building a Huoshenshan hospital and a Leishenshan hospital by about ten days. Huoshenshan means God of fire mountain and Leishenshan means God of thunder mountain. The hope is that the fire and thunder will definitely kill the virus with their power or magic working like holy spirits.
In addition to two new hospitals, many Noah Ark like hospitals were also built to host more than 40 thousand patients infected by COVID-19.
It seemed to me that in China, with the leadership of the Chinese Communist Party and its 89 million party members, the government gives orders, the enterprises cooperate in keeping supply lines and the society echoed all the calls. So the government, enterprises and society united much better than normal times in front of the disasters.
In this sense, I would like to give the credit to the party members because while in dangerous situation, it was always the party members should step forward and face the danger first.
For example, during this anti virus campaign, over 30 thousand doctors and nurses voluntarily answered the call and went to Wuhan to work in those new hospitals. Most of them are party members and many of them who are not would like to join the party on site. This spirit was really moving.
According to reports, due to the uncertainty before the closedown of Wuhan and later with overload of work and stress, by February 11, 3019 doctors and nurses were infected by COVID-19 virus and 1716 cases were confirmed. Among them, 1502 cases were from Hubei province.
During this campaign, nine doctors including two professor doctors, one hospital president died at work. They have become a martyr for us all.
Yesterday I watched the Oct. 18 201 event simulation meeting organized by Johns Hopkins Health Security Center, World Economic Forum and Bill and Melanda Gates Foundation which discussed a lot about how to deal with such kind of serious virus epidemic or pandemic. This show actually caused a lot of conspiracy views which thought America has known this. But I think the discussion mainly focuses on a scenario that the government and business are difficult to form a partnership and the individualism ideas make people difficult to follow the information or guidance.
Indeed there were many rumours and fake news coming out mainly from anti China chinese in America. For example they smear the Wuhan P4 lab for leaking the virus. But as I interviewed Professor Duan from Karolinska Hospital, it is impossible to a P4 lab to leak anything out. It is a very scientifically built lab which has negative pressure which guarantee for the security. As for the scientists, it is also impossible for scientists to have such a low level ethics or break their ethical bottom line.
Some Chinese in America who suffered a setback during Chinas anti corruption campaign or Falungong related people, they only spread their hatrad, presumptions or fabrications plus their imaginations.
It is not difficult to imagine that Chinese hospitals would be extremely busy even during the normal time, let alone under the current situation.
In my opinion, Chinese system is actually functioning well because it is more centralized and the government answered the call of the people quickly and whole heartedly. Under the principle of putting the people’s lives in the center, Chinese economy is definitely affected.
But I think just because it is Spring Festival time, many production stopped anyway, the most damaged industry is tourism and restaurants and hotels. Thus, this effect is felt not only in China, but also many other countries including nordic countries such as Sweden and Finland.
Now since the virus is somewhat under control, it was reported that about 95 percent of production business began to resume.
For example, workers from Xinjiang were sent to Hunan by chartered airplanes with preventive measures. Slowly workers are on the working places now. So far only the students are still at home to enjoy their holidays.
Nowadays schools open earlier than 30 years ago when I was at university. Then the opening of schools was on March first. Nowadays it was usually after the Spring Festival holiday. Due to COVID-19, students can relax a little bit.
Finally about the COVID-19, it is a new kind of virus which was similar to SARS or MERs but not as deadly as those, but it spread faster. It can also spread to other people before you really have symptoms such as coughing, fever and fatigue. Those who are over 80 years old, the infection rate is 14.8%. The younger people are less likely infected. Those who died are mostly having other diseases such as cardiological problems, diabetes and high blood pressure.
The main prevention method is to isolate yourself, often wash your hand, don’t touch your face. It can spread by sneeze or spit. So Dr. Zhong adviced people to even pay attention to your shoes. Try to avoid stepping on any spit.
Where in the world comes the virus from?
So far it is still not clear where the virus comes from. According to early first seven cases, four persons came from a seafood and wildlife trading market, but three others didn’t come from there. The latest research from Yunnan branch of the Chinese Academy of Sciences shows that the virus does not come from that market because their samples show that it is the same as the other three.
Some people suspect that this virus might be the same as the American flu, or another version of the American flu.
But to be honest, no one knows where and when exactly it came from. It can be estimated that the very first spreading of the virus can be on November 27th. Someone said it might start on mid October, but due to the favorable climate, it didn’t break then. Due to the shrewdness of the virus, it can have longer incubation period of 24 days.
Maybe the cold and wet weather in Wuhan just provides the bed for the virus, it is hard to say. We have to wait and see how the scientists and researchers find out through autopsy and sample studies.
北欧绿色邮报网、北欧中华网联合报道（记者陈雪霏 查正富）—11月20日，应世界听神经病鼻祖-美国加州大学Arnold Starr教授的邀请，瑞典皇家卡罗林斯卡Karolinska医科大学医院耳鼻咽喉头颈外科专家段茂利出席了第九届 “Annual Arnold Starr Lecture ＆ Art Exhibition”大会，并做了题为《听神经病的发现历史、发病机制、治疗现状及基因/干细胞治疗听神经病的探索》的精彩报告。这是目前世界上首位华人科学家站在此领域最高讲台作学术报告，刷新了听神经病领域未有华人科学家在此登台“献艺”的空白。
Arnold Starr Lecture ＆ Art Exhibition” 大会并作主旨演讲，我们已仔细观看了您当天演讲同步直播的全过程，非常精彩及惟妙惟肖，我们代表北欧绿色邮报网、北欧中华网对您表示祝贺! 请问这次国际会议在世界医学领域具有怎样的重要地位呢？
Duan：从客观上讲，可能是因为我长期在瑞典卡罗林斯卡大学医院工作，该院的国际地位和国际实力是众所周知的，加上我在基因干细胞研究领域的贡献及自身又是耳鼻咽喉头颈外科专家，同时我又是多个国际性医学杂志的编委及审稿人, 在欧美许多国家著名的大学演讲及交流的经历, 以及这么多年在行业积累的良好口碑，可能也是加分因素之一。从主观上讲，我在听神经病基因干细胞治疗耳聋方面的研究成果得到了国际同行的认可，尤其是创新研究了基因干细胞治疗耳聋，这一疗法既符合Starr教授的研究方向，也是对现有理论成果的进一步探索与挖掘。Starr教授发现了听神经病的一个基因后，医学界发现大量的同类疾病不同的基因。在该病发现之前，人们并不太清楚这种疾病发病的机制，而且在发现的早期，为解除病人痛苦，只是采用助听器进行辅助治疗，没有更科学的医疗手段。因此，我主攻的基因干细胞修复疗法既是学术研究的连续，更是为将来临床实践带来希望。当然，以上纯粹是我个人不成熟的推测，重要的是Starr基金会按照他们的标准和要求来进行挑选的。
记者：两年前Starr教授在斯德哥尔摩(Karolinska Nobel Forum)诺贝尔演讲厅的研讨会上用艺术彩色图形来展示耳部神经系统，您今年这次演讲似乎也很倾向艺术化啊！
STOCKHOLM, Nov. 20(Greenpost)– Ma Jianzhong, Chairman of World Federation of Chinese Medicine Societies (WFCMS) led a large delegation of over 30 members to visit Sweden in order to make academic exchanges and field study on November 13th.
This was right after they attended the 16th World Congress of Chinese Medicine which was successfully held in Budapest, Capital of Hungary. The delegation includes leading experts and specialists in the field of Chinese medicine.
At 10:30 in the morning, Chairman Ma Jianzhong, former Vice Minister of Health, Professor She Jing, who was also founding Chairman of the World Federation of Chinese Medicine Societies, and Professor Li Zhenji, Vice founding Chairman and Secretary-General of WFCMS and other six people came to the Chinese Embassy in Stockholm at the invitation of Chinese Ambassador Gui Cuiyou.
They were warmly welcomed and Ambassador Gui made extensive talks on the development of traditional Chinese medicine acupuncture and moxibustion in Sweden, and further explored how to further promote Chinese medicine culture and relieve the suffering of the Swedish people and overseas Chinese.
Counselor Dai Gang of Science and Technology at the Embassy and President Yang Chungui of the Swedish Society of Chinese Medicine gave a detailed introduction about the operation of Swedish traditional Chinese medicine and acupuncture clinics and the exchanges and cooperation with Western doctors such as those from Karolinska Hospital.
Jiemei, a lawyer at Guohao Law Firm, introduced the work of promoting acupuncture legislation in Sweden. After the talks, the Embassy arranged a lunch for all the guests.
After thorough inspection by the leaders of the World Federation of China and the friendly consultation between the two sides, they jointly decided that the World Federation of Chinese Medicine Professional Level Recognition Department and the Swedish Society of Chinese Medicine will sign a cooperation framework agreement on the “Cooperation on the clinical superiority technology transfer of traditional Chinese medicine and the evaluation of professional titles of international Chinese medicine”.
At 3 o’clock in the afternoon, under the witnesses of the WFCMS’ leaders and Guo Hao law Firm’s lawyer Jiemei, Professor Zheng Yuexian, the chief expert of the WFCMS and President of the Swedish Association of Chinese Medicine, Yang Chungui signed this important agreement.
On the morning of the 14th, the World Federation of Chinese Medicine Societies experts visited Karolinska Institutet. The former Nobel Prize jury chair Professor Silas introduced the Karolinska Institute and Nobel Prize evaluation process to the delegation.
In the afternoon, the delegation concluded the intense academic study tour and flew back to China with Air China.
The World Federation of Chinese Medicine Societies is an international academic organization approved by the Chinese State Council and a member of the World Health Organization. It’s a Non-Governmental Organization (NGO).
STOCKHOLM， Sept. 24 (Greenpost) — Shenzhen Promotion and Communication Presentation was held in Stockholm on Tuesday.
Zhang Qiaozhen, President of the General Chamber of Commerce, Cao Diefeng, Counsular of Education at the Chinese Embassy, Fan Kun, Vice President of Shenzhen Overseas Communication Association and dozens of masters or Phd students from universities in Stockholm attended the presentation.
President Zhang congratulated the presentation. She explained that the goal of her Nordic-Shenzhen General Chamber of Commerce is to promote the communication between Shenzhen and Nordic countries. We have helped nordic enterprises to go to Shenzhen and Guangzhou to attend trade and high tech fairs as well as cultural exhibitions。Today we have Shenzhen delegation coming to Sweden to present Shenzhen to you. Let’s welcome Fan Kun, Vice President of Shenzhen Overseas Communication Association.
Fan Kun said Shenzhen used to be a small fishing village with a population of only 30 thousand. Now it is one of the most innovative cities all over China.
Shenzhen aims to become a roll model for Chinese cities by 2030 and 2049 and it can even be the world’s model city. Shenzhen has wonderful environment with the lowest in PM 2.5. The city is very young and vital. It is very good for young talented people to work in Shenzhen. The treatment is very good if you can have good project or achievement, said Fan.
Counsular Cao encouraged the students to go to Shenzhen to work saying that they can have a good communication to take this opportunity.
Liu Huadian from Shenzhen Overseas Communication Association said the average age in Shenzhen is just 33 years old. So the city is the youngest one in China. The net increase of population reached by half a million to over 13 million . There are many volunteers in Shenzhen and people from Hong Kong, Macao and Taiwan reached 150 thousand by the end of last year. Shenzhen is very open and all the information about talented people from overseas are published on website.
They also answered questions from the students.
Shenzhen has become an admirable city for talented people. The exchange and promotion seminar was organized by Shenzhen Overseas Communication Association.